The tandem repeated irritation test: a new method to assess prevention of irritant combination damage to the skin

Authors

  • Walter Wigger-Alberti
  • Julia Spoo
  • Sibylle Schliemann-Willers
  • Andreas Klotz
  • Peter Elsner

DOI:

https://doi.org/10.1080/00015550252948103

Abstract

The effect of a protective cream was tested in a new tandem repeated irritation test with tandem application of 0.5% sodium lauryl sulphate (SLS) and undiluted toluene. The irritants were applied twice daily for 30 min to the ventral forearms of 20 volunteers. Irritant cutaneous reactions were quantified by a visual score, transepidermal water loss, chromametry and skin capacitance. Concurrent application of SLS/toluene induced stronger reactions than those caused by twice daily application of each irritant on its own. A protective effect of the protective cream was obtained against all treatment combinations and was significant for SLS/SLS (p < or = 0.01) and SLS/ toluene (p < or = 0.05). Our results indicate that the tandem repetitive irritation test has great potential in the evaluation of skin care products to prevent irritant contact dermatitis.

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Published

2002-07-20

How to Cite

Wigger-Alberti, W., Spoo, J., Schliemann-Willers, S., Klotz, A., & Elsner, P. (2002). The tandem repeated irritation test: a new method to assess prevention of irritant combination damage to the skin. Acta Dermato-Venereologica, 82(2), 94–97. https://doi.org/10.1080/00015550252948103

Issue

Vol. 82 No. 2 (2002)

Section

Articles

License

All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.

Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.

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