Kinetics of phototoxicity in trioxysalen bath psoralen plus ultraviolet A photochemotherapy
DOI:
https://doi.org/10.1080/000155501750376230Abstract
A trioxysalen bath is a safe alternative to systemic 8-methoxypsoralen in long-term psoralen plus ultraviolet A (PUVA) treatment. The kinetics of its main side-effect, the strong phototoxicity, has not been thoroughly studied. This study determined the degree and persistence of phototoxicity after a single 10 min bath at a trioxysalen concentration of 0.33 mg/l. The buttock skin of 16 healthy volunteers was irradiated with UVA 10 min, and 1, 3, 9 and 24h after the bath. The minimal phototoxic dose (MPD) was assessed 48, 72 and 96h after the bath. In general, the 96 h reading showed the lowest values of MPDDownloads
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Published
2001-05-20
How to Cite
Snellman, E., & Rantanen, T. (2001). Kinetics of phototoxicity in trioxysalen bath psoralen plus ultraviolet A photochemotherapy. Acta Dermato-Venereologica, 81(3), 171–174. https://doi.org/10.1080/000155501750376230
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