Elevated Granulysin Expression in Cytotoxic Lymphocytes from the Blood and Lesions of Patients with Lichen Planus

Authors

  • Marijana Vičić
  • Ines Brajac
  • Marija Kaštelan
  • Vlatka Sotošek
  • Larisa Prpić Massari Department of Dermatovenereology, Clinical Hospital Center Rijeka, HR-51000 Rijeka, Croatia

DOI:

https://doi.org/10.2340/00015555-3863

Abstract

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References

Tziotzios C, Lee JYW, Brier T, Saito R, Hsu CK, Bhargava K, et al. Lichen planus and lichenoid dermatoses: clinical overview and molecular basis. J Am Acad Dermatol 2018; 79: 789–804.

Carozzo M. Understanding the pathobiology of oral lichen planus. Curr Oral Health Rep 2014; 1: 173–179.

Shao S, Tsoi LC, Sarkar MK, Xing X, Xue K, Uppala R, et al. IFN-gamma enhances cell-mediated cytotoxicity against keratinocytes via JAK2/STAT1 in lichen planus. Sci Transl Med 2020; 25; 11: eaav7561.

Lage D, Pimentel VN, Soares TC, Souza EM, Metze K, Cintra ML. Perforin and granzyme B expression in oral and cutaneous lichen planus – a comparative study. J Cutan Pathol 2011; 38: 973–978.

Kaštelan M, Prpić Massari L, Gruber F, Zamolo G, Zauhar G, Coklo M, et al. The role of perforin-mediated apoptosis in lichen planus lesions. Arch Dermatol Res 2004; 296: 226–230.

Shimizu M, Higaki Y, Higaki M, Kawashima M. The role of granzyme B-expressing CD8-positive T cells in apoptosis of keratinocytes in lichen planus. Arch Dermatol Res 1997; 289: 527–532.

Prpić Massari L, Kaštelan M, Gruber F, Laskarin G, Sotosek Tokmadzić V, Strbo N, et al. Perforin expression in peripheral blood lymphocytes and skin-infiltrating cells in patients with lichen planus. Br J Dermatol 2004; 151: 433–439.

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Vicic M, Kastelan M, Sotosek Tokmadžic V, Prpic Massari L. Systemic and local increase of granulysin expression in cytotoxic lymphocytes in severe psoriasis. Acta Derm Venereol 2019; 99: 1136–1142.

Zhou XJ, Sugerman PB, Savage NW, Walsh LJ, Seymour GJ. Intra-epithelial CD8+ T cells and basement membrane disruption in oral lichen planus. J Oral Pathol Med 2002; 31: 23–27.

Santoro A, Majorana A, Bardellini E, Gentili F, Festa S, Sapelli P, et al. Cytotoxic molecule expression and epithelial cell apoptosis in oral and cutaneous lichen planus. Am J Clin Pathol 2004; 121: 758–764.

Hussein MR, Aboulhagag NM, Atta HS, Atta SM. Evaluation of the profile of the immune cell infiltrate in lichen planus, discoid lupus erythematosus, and chronic dermatitis. Pathology 2008; 40: 682–693.

Chung WH, Hung SI. Recent advances in the genetics and immunology of Stevens-Johnson syndrome and toxic epidermal necrosis. J Dermatol Sci 2012; 66: 190–196.

Published

2021-07-13

How to Cite

Vičić, M., Brajac, I., Kaštelan, M., Sotošek, V., & Prpić Massari, L. (2021). Elevated Granulysin Expression in Cytotoxic Lymphocytes from the Blood and Lesions of Patients with Lichen Planus. Acta Dermato-Venereologica, 101(7), adv00499. https://doi.org/10.2340/00015555-3863

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