Early Detection of Epidermal Dust-Like Particles in Experimentally UV-Induced Lesions in Patients with Photosensitivity and Lupus Erythematosus.
DOI:
https://doi.org/10.1080/000155598441477Abstract
Dust-like particles;producing a specific fine-speckled;epidermo-subepidermal direct immunofluorescence staining pattern;have been associated mainly with subacute cutaneous lupus erythematosus (LE). Under experimental conditions the appearance of immunoglobulins along the basement membrane in ultraviolet (UV) light-induced lesions has been reported as a late phenomenon. In this study;photoprovocations with UVA and UVB light were carried out in 16 photosensitive patients with discoid (n = 13);subacute cutaneous (n = 2) or systemic LE (n = 1) and serial biopsies from UV-induced lesions were processed for direct immunofluorescence. A specific;fine-speckled epidermal staining was detected within 7 to 14 days after UV provocation in 7/16 of the patientsDownloads
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