Effect of Dietary Supplementation with Omega-3 Fatty Acid and Gamma-linolenic Acid on Acne Vulgaris: A Randomised, Double-blind, Controlled Trial

Authors

  • Jae Yoon Jung
  • Hyuck Hoon Kwon
  • Jong Soo Hong
  • Ji Young Yoon
  • Mi Sun Park
  • Mi Young Jang
  • Dae Hun Suh

DOI:

https://doi.org/10.2340/00015555-1802

Keywords:

acne, &#947, -linoleic acid, omega-3 fatty acid.

Abstract

This study was undertaken to evaluate the clinical efficacy, safety, and histological changes induced by dietary omega-3 fatty acid and γ-linoleic acid in acne vulgaris. A 10-week, randomised, controlled parallel dietary intervention study was performed in 45 participants with mild to moderate acne, which were allocated to either an omega-3 fatty acid group (2,000 mg of eicosapentaenoic acid and docosahexaenoic acid), a γ-linoleic acid group (borage oil containing 400 mg γ-linoleic acid), or a control group. After 10 weeks of omega-3 fatty acid or γ-linoleic acid supplementation, inflammatory and non-inflammatory acne lesions decreased significantly. Patient subjective assessment of improvement showed a similar result. Heamatoxylin & eosin staining of acne lesions demonstrated reductions in inflammation and immunohistochemical staining intensity for interleukin-8. No severe adverse effect was reported. This study shows for the first time that omega-3 fatty acid and γ-linoleic acid could be used as adjuvant treatments for acne patients.

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Published

2014-01-29

How to Cite

Yoon Jung, J., Hoon Kwon, H., Soo Hong, J., Young Yoon, J., Sun Park, M., Young Jang, M., & Hun Suh, D. (2014). Effect of Dietary Supplementation with Omega-3 Fatty Acid and Gamma-linolenic Acid on Acne Vulgaris: A Randomised, Double-blind, Controlled Trial. Acta Dermato-Venereologica, 94(5), 521–525. https://doi.org/10.2340/00015555-1802

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Articles