Feasibility of Measuring Lipophilic Or Protein-Bound Drugs in the Dermis by in Vivo Microdialysis After Topical Or Systemic Drug Administration.
DOI:
https://doi.org/10.1080/000155598441855Abstract
Our aim was to assess the microdialysis technique for determining in vivo drug levels of a lipophilic and a protein-bound model drug in the dermis. Forearm skin of healthy volunteers received topical 2% fusidic acid or 0.1% betamethasone-17-valerate formulations twice daily as occluded treatment on irritative dermatitis. Microdialysis sampling in the dermis after 48 h was without measurable drug. Hairless rats received maximized treatment with occluded applications of 10% fusidic acid or 4% betamethasone-17-valerate in ethanol for 72 h followed by microdialysis. Mean levels of betamethasone-17-valerate were 11-45 ng/mlDownloads
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Published
1998-08-05
How to Cite
Benfeldt, E., & Groth, L. (1998). Feasibility of Measuring Lipophilic Or Protein-Bound Drugs in the Dermis by in Vivo Microdialysis After Topical Or Systemic Drug Administration. Acta Dermato-Venereologica, 78(4), 274–278. https://doi.org/10.1080/000155598441855
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