Prevalence and Characteristics of Hidradenitis Suppurativa in the Northern Finland Birth Cohort 1986 Study: A Cross-sectional Study of 2,775 Subjects
DOI:
https://doi.org/10.2340/actadv.v104.14732Keywords:
hidradenitis suppurativa, characteristics, risk factors, overall health, general population, cohort study, prevalenceAbstract
A negative stigmatization related to hidradenitis suppurativa may prevent patients from seeking care. Thus, a large proportion of patients with hidradenitis suppurativa may be missing from studies based on hospital data. The aim of this study was to examine the prevalence and characteristics of hidradenitis suppurativa among 2,775 subjects in the Northern Finland Birth Cohort 1986 Study (NFBC1986), who were in their mid-thirties. The prevalence of hidradenitis suppurativa was 4.0% (n = 110/2,775), being higher in females (4.8%) than in males (2.5%) (p < 0.01). Of those defined as having hidradenitis suppurativa in this study, only 4 cases (n = 4/110, 3.6%) were found to have a hidradenitis suppurativa diagnosis either in the hospital (Care Register for Health Care) or in the primary healthcare data. In an adjusted model in logistic regression analyses, hidradenitis suppurativa was significantly associated with obesity (body mass index 30–55 kg/m2) (odds ratio 3.81, 95% confidence interval 2.80–5.22), female sex (1.99, 1.53–2.61) and smoking (1.56, 1.21–2.00). In addition, there was an association between hidradenitis suppurativa and self-reported poor overall health status. Hidradenitis suppurativa seems to be common at the population level and only a minority of these patients seek care for the condition.
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Jemec GBE, Kimball AB. Hidradenitis suppurativa: epidemiology and scope of the problem. J Am Acad Dermatol 2015; 73: 4-7.
https://doi.org/10.1016/j.jaad.2015.07.052 DOI: https://doi.org/10.1016/j.jaad.2015.07.052
Hirvonen MJ, Pasternack R, Lipitsä T, Vihervaara A, Harvima R, Ranta M, et al. Patients with hidradenitis suppurativa suffer from low health-related quality of life as measured by the generic 15D instrument. Skin Appendage Disord 2022; 8: 221-227.
https://doi.org/10.1159/000520839 DOI: https://doi.org/10.1159/000520839
Huilaja L, Tiri H, Jokelainen J, Timonen M, Tasanen K. Patients with hidradenitis suppurativa have a high psychiatric disease burden: a Finnish Nationwide Registry Study. J Invest Dermatol 2018; 138: 46-51.
https://doi.org/10.1016/j.jid.2017.06.020 DOI: https://doi.org/10.1016/j.jid.2017.06.020
Vazquez BG, Alikhan A, Weaver AL, Wetter DA, Davis MD. Incidence of hidradenitis suppurativa and associated factors: a population-based study of Olmsted County, Minnesota. J Invest Dermatol 2013; 133: 97-103.
https://doi.org/10.1038/jid.2012.255 DOI: https://doi.org/10.1038/jid.2012.255
Garg A, Kirby JS, Lavian J, Lin G, Strunk A. Sex- and age-adjusted population analysis of prevalence estimates for hidradenitis suppurativa in the United States. JAMA Dermatol 2017; 153: 760-764.
https://doi.org/10.1001/jamadermatol.2017.0201 DOI: https://doi.org/10.1001/jamadermatol.2017.0201
Wiseman MC. Hidradenitis suppurativa: a review. Dermatol Ther 2004; 17: 50-54.
https://doi.org/10.1111/j.1396-0296.2004.04007.x DOI: https://doi.org/10.1111/j.1396-0296.2004.04007.x
Garg A, Malviya N, Strunk A, Wright S, Alavi A, Alhusayen R, et al. Comorbidity screening in hidradenitis suppurativa: evidence-based recommendations from the US and Canadian Hidradenitis Suppurativa Foundations. J Am Acad Dermatol 2022; 86: 1092-1101.
https://doi.org/10.1016/j.jaad.2021.01.059 DOI: https://doi.org/10.1016/j.jaad.2021.01.059
Revuz JE, Canoui-Poitrine F, Wolkenstein P, Viallette C, Gabison G, Pouget F, et al. Prevalence and factors associated with hidradenitis suppurativa: results from two case-control studies. J Am Acad Dermatol 2008; 59: 596-601.
https://doi.org/10.1016/j.jaad.2008.06.020 DOI: https://doi.org/10.1016/j.jaad.2008.06.020
Garg A, Neuren E, Cha D, Kirby JS, Ingram JR, Jemec GBE, et al. Evaluating patients' unmet needs in hidradenitis suppurativa: results from the Global Survey Of Impact and Healthcare Needs (VOICE) Project. J Am Acad Dermatol 2020; 82: 366-376.
https://doi.org/10.1016/j.jaad.2019.06.1301 DOI: https://doi.org/10.1016/j.jaad.2019.06.1301
NFBC 1986 Data Collection. Northern Finland Cohorts. [accessed 2022 May 30] Available from: https://www.oulu.fi/en/university/faculties-and-units/faculty-medicine/northern-finland-birth-cohorts-and-arctic-biobank/research-program-health-and-well-being.
Vinding GR, Miller IM, Zarchi K, Ibler KS, Ellervik C, Jemec GBE. The prevalence of inverse recurrent suppuration: a population-based study of possible hidradenitis suppurativa. Br J Dermatol 2014; 170: 884-889.
https://doi.org/10.1111/bjd.12787 DOI: https://doi.org/10.1111/bjd.12787
Saunders JB, Aasland O, Babor T, de la Fuente J, Grant M. Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption - II. Addiction (Abingdon, England) 1993; 88: 791-804.
https://doi.org/10.1111/j.1360-0443.1993.tb02093.x DOI: https://doi.org/10.1111/j.1360-0443.1993.tb02093.x
Theut Riis P, Pedersen OB, Sigsgaard V, Erikstrup C, Paarup HM, Nielsen KR, et al. Prevalence of patients with self-reported hidradenitis suppurativa in a cohort of Danish blood donors: a cross-sectional study. Br J Dermatol 2019; 180: 774-781.
https://doi.org/10.1111/bjd.16998 DOI: https://doi.org/10.1111/bjd.16998
Jemec GB. The symptomatology of hidradenitis suppurativa in women. Br J Dermatol 1988; 119: 345-350.
https://doi.org/10.1111/j.1365-2133.1988.tb03227.x DOI: https://doi.org/10.1111/j.1365-2133.1988.tb03227.x
Jemec GB, Heidenheim M, Nielsen NH. The prevalence of hidradenitis suppurativa and its potential precursor lesions. J Am Acad Dermatol 1996; 35: 191-194.
https://doi.org/10.1016/S0190-9622(96)90321-7 DOI: https://doi.org/10.1016/S0190-9622(96)90321-7
Riis P, Ring H. Themstrup L, Jemec GB. The role of androgens and estrogens in hidradenitis suppurativa - a systematic review. Acta Dermatovenereol Croat 2016; 24: 239-249.
Alikhan A, Lynch PJ, Eisen DB. Hidradenitis suppurativa: a comprehensive review. J Am Acad Dermatol 2009; 60: 539-561.
https://doi.org/10.1016/j.jaad.2008.11.911 DOI: https://doi.org/10.1016/j.jaad.2008.11.911
Mokos ZB, Miše J, Balić A, Marinović B. Understanding the relationship between smoking and hidradenitis suppurativa. Acta Dermatovenerol Croat 2020; 28: 9-13.
Deckers I, Janse I, van der Zee H, Nijsten T, Boer J, Horváth B, et al. Hidradenitis suppurativa (HS) is associated with low socioeconomic status (SES): a cross-sectional reference study. J Am Acad Dermatol 2016; 75: 755-759.
https://doi.org/10.1016/j.jaad.2016.04.067 DOI: https://doi.org/10.1016/j.jaad.2016.04.067
Adler NE, Boyce T, Chesney MA, Cohen S, Folkman S, Kahn RL, et al. Socioeconomic status and health: the challenge of the gradient. American Psychologist 1994; 49: 15-24.
https://doi.org/10.1037/0003-066X.49.1.15 DOI: https://doi.org/10.1037/0003-066X.49.1.15
Kluger N, Ranta M, Serlachius M. The burden of hidradenitis suppurativa in a cohort of patients in southern Finland: a pilot study 2017. Skin Appendage Disord 2017; 3: 20-27.
https://doi.org/10.1159/000455236 DOI: https://doi.org/10.1159/000455236
Samela T, Dattolo A, Cordella G, Antinone V, Mastroeni S, Fusari R, et al. Similar levels of disease severity correspond to a greater burden of illness in women compared with men with hidradenitis suppurativa. Acta Derm Venereol 2023; 103: adv00856.
https://doi.org/10.2340/actadv.v103.2558 DOI: https://doi.org/10.2340/actadv.v103.2558
Tiri H, Huilaja L, Jokelainen J, Timonen M, Tasanen K. Women with hidradenitis suppurativa have an elevated risk of suicide. J Invest Dermatol 2018; 138: 2672-2674.
https://doi.org/10.1016/j.jid.2018.06.171 DOI: https://doi.org/10.1016/j.jid.2018.06.171
Nordström T, Auvinen J, Ala-Mursula L, Keinänen-Kiukaanniemi S, Veijola J, Järvelin MR et al. Cohort Profile: 46 years of follow-up of the Northern Finland Birth Cohort 1966 (NFBC1966). Int J Epidemiol 2021; 50: 1-12.
https://doi.org/10.1093/ije/dyab109 DOI: https://doi.org/10.1093/ije/dyab109
Mindell JS, Giampaoli S, Goesswald A, Kamtsiuris P, Mann C, Mannisto S, et al. Sample selection, recruitment and participation rates in health examination surveys in Europe - experience from seven national surveys. BMC Med Res Methodol 2015; 15: 74-78.
https://doi.org/10.1186/s12874-015-0072-4 DOI: https://doi.org/10.1186/s12874-015-0072-4
Koptyev J, Strunk A, Garg A. Low predictive value of questionnaire-based diagnosis of hidradenitis suppurativa. Br J Dermatol 2022; 187: 1015-1017.
https://doi.org/10.1111/bjd.21787 DOI: https://doi.org/10.1111/bjd.21787
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