Association of Actinic Keratosis with Rheumatoid Arthritis and Psoriasis: A Nationwide Population-Based Study in Korea


  • Hyun Jee Kim
  • Yeong Ho Kim
  • So Yeon Yun
  • Dong Soo Yu
  • Young Bok Lee Department of Dermatology, College of Medicine, The Catholic University of Korea, 07345 Uijeongbu, Korea



actinic keratosis, psoriasis, rheumatoid arthritis


There have been no epidemiological studies identifying associations between systemic inflammatory diseases and actinic keratosis. This study used a large nationwide database to investigate the associations between actinic keratosis and systemic inflammatory diseases. Records of patients over 20 years of age newly diagnosed with actinic keratosis (n = 64,659) from 2012 to 2017 were analysed. A control population of individuals without actinic keratosis, matched for age, sex, and year of claim, who visited an outpatient clinic, was sampled at a ratio of 1:1 (n = 64,659). Both cohorts were analysed for the presence of systemic inflammatory diseases within at least 5 years prior to diagnosis of actinic keratosis. Patients with actinic keratosis exhibited higher odds ratios for rheumatoid arthritis (1.336; 95% confidence interval (95% CI) 1.161–1.537)) and psoriasis (1.513; 95% CI 1.435–1.595) compared with the control group on multivariate analysis. However, the proportions of Behçet’s disease, Crohn’s disease, ulcerative colitis, and multiple sclerosis in the actinic keratosis group were not statistically significant.


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How to Cite

Kim, H. J., Kim , Y. H., Yun, S. Y., Yu, D. S., & Lee, Y. B. (2021). Association of Actinic Keratosis with Rheumatoid Arthritis and Psoriasis: A Nationwide Population-Based Study in Korea. Acta Dermato-Venereologica, 101(7), adv00510.