Association of Actinic Keratosis with Rheumatoid Arthritis and Psoriasis: A Nationwide Population-Based Study in Korea
DOI:
https://doi.org/10.2340/00015555-3877Keywords:
actinic keratosis, psoriasis, rheumatoid arthritisAbstract
There have been no epidemiological studies identifying associations between systemic inflammatory diseases and actinic keratosis. This study used a large nationwide database to investigate the associations between actinic keratosis and systemic inflammatory diseases. Records of patients over 20 years of age newly diagnosed with actinic keratosis (n = 64,659) from 2012 to 2017 were analysed. A control population of individuals without actinic keratosis, matched for age, sex, and year of claim, who visited an outpatient clinic, was sampled at a ratio of 1:1 (n = 64,659). Both cohorts were analysed for the presence of systemic inflammatory diseases within at least 5 years prior to diagnosis of actinic keratosis. Patients with actinic keratosis exhibited higher odds ratios for rheumatoid arthritis (1.336; 95% confidence interval (95% CI) 1.161–1.537)) and psoriasis (1.513; 95% CI 1.435–1.595) compared with the control group on multivariate analysis. However, the proportions of Behçet’s disease, Crohn’s disease, ulcerative colitis, and multiple sclerosis in the actinic keratosis group were not statistically significant.
Downloads
References
Lee JH, Kim YH, Han KD, Park YM, Lee JY, Park YG, et al. Incidence of actinic keratosis and risk of skin cancer in subjects with actinic keratosis: a population-based cohort study. Acta Derm Venereol 2018; 98: 382–383.
Neto PD, Alchorne M, Michalany N, Abreu M, Borra R. Reduced P53 staining in actinic keratosis is associated with squamous cell carcinoma: a preliminary study. Indian J Dermatol 2013; 58: 325.
Gellen E, Fidrus E, Peter M, Szegedi A, Emri G, Remenyik E. Immunological effects of photodynamic therapy in the treatment of actinic keratosis and squamous cell carcinoma. Photodiagnosis Photodyn Ther 2018; 24: 342–348.
Cantisani C, Paolino G, Melis M, Faina V, Romaniello F, Didona D, et al. Actinic keratosis pathogenesis update and new patents. Recent Pat Inflamm Allergy Drug Discov 2016; 10: 40–48.
Butler GJ, Neale R, Green AC, Pandeya N, Whiteman DC. Nonsteroidal anti-inflammatory drugs and the risk of actinic keratoses and squamous cell cancers of the skin. J Am Acad Dermatol 2005; 53: 966–972.
Tuong ZK, Lewandowski A, Bridge JA, Cruz JLG, Yamada M, Lambie D, et al. Cytokine/chemokine profiles in squamous cell carcinoma correlate with precancerous and cancerous disease stage. Sci Rep 2019; 9: 17754.
Lee Y, Lee J, Choi J, Yu D, Han K, Park YG. Actinic keratosis and diabetes complications: a nationwide population-based study in South Korea (2009–2015). Diabetes Metab 2019; 45: 32–38.
Lee YB, Lee JH, Kang MJ, Kim JW, Yu DS, Han KD, et al. Association between height and actinic keratosis: a nationwide population-based study in South Korea. Sci Rep 2018; 8: 10897.
de Oliveira ECV, da Motta VRV, Pantoja PC, Ilha CSO, Magalhaes RF, Galadari H, et al. Actinic keratosis – review for clinical practice. Int J Dermatol 2019; 58: 400–407.
Berman B, Cockerell CJ. Pathobiology of actinic keratosis: ultraviolet-dependent keratinocyte proliferation. J Am Acad Dermatol 2013; 68: S10–19.
Liu YT, Tsou HK, Chiou JY, Wang YH, Chou MC, Wei JC. Association of human papillomavirus infection with risk for rheumatoid arthritis: a population-based cohort study. Ann Rheum Dis 2019; 78: 1734–1736.
Ceccarelli F, Saccucci M, Di Carlo G, Lucchetti R, Pilloni A, Pranno N, et al. Periodontitis and rheumatoid arthritis: the same inflammatory mediators? Mediators Inflamm 2019; 2019: 6034546.
Corcorran MA, Olson JM, Hecht C, Knezevich S, Vary JC. Eruptive squamous cell carcinoma in a patient receiving abatacept for rheumatoid arthritis. J Am Acad Dermatol 2013; 69: e178–179.
Flendrie M, Vissers WH, Creemers MC, de Jong EM, van de Kerkhof PC, van Riel PL. Dermatological conditions during TNF-alpha-blocking therapy in patients with rheumatoid arthritis: a prospective study. Arthritis Res Ther 2005; 7: R666–R676.
Georgescu SR, Tampa M, Caruntu C, Sarbu MI, Mitran CI, Mitran MI, et al. Advances in understanding the immunological pathways in psoriasis. Int J Mol Sci 2019; 20: 739.
Deng Y, Chang C, Lu Q. The inflammatory response in psoriasis: a comprehensive review. Clin Rev Allergy Immunol 2016; 50: 377–389.
Paltiel O, Adler B, Herschko K, Tsukrov B, David M. Are patients with psoriasis susceptible to the classic risk factors for actinic keratoses? Arch Dermatol 2004; 140: 805–810.
Belbasis L, Dosis V, Evangelou E. Elucidating the environmental risk factors for rheumatic diseases: an umbrella review of meta-analyses. Int J Rheum Dis 2018; 21: 1514–1524.
De Hertog SA, Wensveen CA, Bastiaens MT, Kielich CJ, Berkhout MJ, Westendorp RG, et al. Relation between smoking and skin cancer. J Clin Oncol 2001; 19: 231–238.
Zeng J, Luo S, Huang Y, Lu Q. Critical role of environmental factors in the pathogenesis of psoriasis. J Dermatol 2017; 44: 863–872.
Additional Files
Published
How to Cite
License
Copyright (c) 2021 Hyun Jee Kim, Yeong Ho Kim , So Yeon Yun, Dong Soo Yu, Young Bok Lee
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.
Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.
