Association of Actinic Keratosis with Rheumatoid Arthritis and Psoriasis: A Nationwide Population-Based Study in Korea

Authors

  • Hyun Jee Kim
  • Yeong Ho Kim
  • So Yeon Yun
  • Dong Soo Yu
  • Young Bok Lee Department of Dermatology, College of Medicine, The Catholic University of Korea, 07345 Uijeongbu, Korea https://orcid.org/0000-0002-8642-2479

DOI:

https://doi.org/10.2340/00015555-3877

Keywords:

actinic keratosis, psoriasis, rheumatoid arthritis

Abstract

There have been no epidemiological studies identifying associations between systemic inflammatory diseases and actinic keratosis. This study used a large nationwide database to investigate the associations between actinic keratosis and systemic inflammatory diseases. Records of patients over 20 years of age newly diagnosed with actinic keratosis (n = 64,659) from 2012 to 2017 were analysed. A control population of individuals without actinic keratosis, matched for age, sex, and year of claim, who visited an outpatient clinic, was sampled at a ratio of 1:1 (n = 64,659). Both cohorts were analysed for the presence of systemic inflammatory diseases within at least 5 years prior to diagnosis of actinic keratosis. Patients with actinic keratosis exhibited higher odds ratios for rheumatoid arthritis (1.336; 95% confidence interval (95% CI) 1.161–1.537)) and psoriasis (1.513; 95% CI 1.435–1.595) compared with the control group on multivariate analysis. However, the proportions of Behçet’s disease, Crohn’s disease, ulcerative colitis, and multiple sclerosis in the actinic keratosis group were not statistically significant.

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References

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Published

2021-07-30

How to Cite

Kim, H. J., Kim , Y. H., Yun, S. Y., Yu, D. S., & Lee, Y. B. (2021). Association of Actinic Keratosis with Rheumatoid Arthritis and Psoriasis: A Nationwide Population-Based Study in Korea. Acta Dermato-Venereologica, 101(7), adv00510. https://doi.org/10.2340/00015555-3877