Morphology of endogenous flare-up reactions in contact allergy to gold.
DOI:
https://doi.org/10.2340/0001555577474479Abstract
In a double-blind study, 20 patients with contact allergy to gold were given an intramuscular injection of gold sodium thiomalate or placebo, inducing a clinical and histological flare-up of healed patch test sites in the gold-injected but not in the placebo group. The test area of the placebo group showed some perivascular lymphocytic foci (UCHL-1+) and vascular endothelial ELAM-1 staining. The gold group, with flare-up, showed larger and more extensive lymphocytic foci with ELAM-1+ endothelium as well as lymphocytic epidermotropism. CD1a+ LC cells were downgraded, tryptase+ mast cells accumulated and CD68+ monocytes/macrophages markedly increased. Probably, a significant part of the tissue priming as a result of patch testing comprises memory T-cells and endothelial ELAM-1 upgrading, but blood-borne CD68+ monocytes may also be instrumental in the flare-up.Downloads
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Published
1997-12-12
How to Cite
Larsson, A., Möller, H., Björkner, B., & Bruze, M. (1997). Morphology of endogenous flare-up reactions in contact allergy to gold. Acta Dermato-Venereologica, 77(6), 474–479. https://doi.org/10.2340/0001555577474479
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