The effect of calcipotriol on lesional fibroblasts from patients with active morphoea.
DOI:
https://doi.org/10.2340/000155557575364366Abstract
We examined the responsiveness of cultured dermal fibroblasts from biopsies of 6 patients with active morphoea and a similar number of matched controls to the cell proliferation inhibition activity of calcipotriol. Cultured fibroblasts from controls showed no significant response to calcipotriol (at concentrations of 1 x 10(-8) to 1 x 10(-4) M). However, calcipotriol did inhibit the proliferation response of morphoea fibroblasts at all concentrations when compared with controls. There was 4- to 20-fold inhibition in 2 of the morphoea patients when compared with control samples. Four other morphoea samples showed inhibition but to a lesser extent compared with controls.Downloads
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Published
1995-09-01
How to Cite
Bottomley, W. W., Jutley, J., Wood, E. J., & Goodfield, M. D. (1995). The effect of calcipotriol on lesional fibroblasts from patients with active morphoea. Acta Dermato-Venereologica, 75(5), 364–366. https://doi.org/10.2340/000155557575364366
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