The induction of epidermal ornithine decarboxylase following UV/B irradiation is inhibited by estriol.
DOI:
https://doi.org/10.2340/00015555739293Abstract
The induction of epidermal ornithine decarboxylase (ODC) can be partially blocked by corticosteroids, retinoic acid or active vitamin D3. The influence of the other members of this so/called "steroid hormone receptor superfamily", namely the sex/steroids and thyroid hormone, is unknown in epidermis, but they enhance ODC induction in certain other tissues. Here we investigated whether topical estriol leads to a spontaneous and/or enhanced epidermal ODC induction 8 h after UV/B irradiation of 6 postmenopausal women. Contrary to expectation, estriol did not stimulate induction but reduced induction by 44%. This observation raises the possibility that all members of the steroid hormone receptor superfamily may share a common AP/1 binding site.Downloads
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Published
1993-04-01
How to Cite
Arnold, W. P., Pennings, B. J., & van de Kerkhof, P. C. (1993). The induction of epidermal ornithine decarboxylase following UV/B irradiation is inhibited by estriol. Acta Dermato-Venereologica, 73(2), 92–93. https://doi.org/10.2340/00015555739293
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