Recurrent condylomata acuminata treated with recombinant interferon alpha/2a. A multicenter double/blind placebo/controlled clinical trial. Condylomata International Collaborative Study Group.
DOI:
https://doi.org/10.2340/0001555573223226Abstract
A randomized, double/blind, placebo/controlled, international multicenter trial was conducted, using 1.5 MIU subcutaneous interferon alpha/2a 3 times a week for 4 weeks in 170 patients (interferon, n = 125 or placebo, n = 45) with condylomata acuminata who had failed to respond to standard therapies. There was no difference in efficacy between the interferon alpha/2a and placebo treatment groups at 3 months after commencement of therapy. Although the recurrence rate at the end of 9 months' follow/up appeared lower in the interferon alpha/2a group than in the placebo group (9% versus 22%), this difference was not statistically significant. Most of the adverse events reported were typical interferon/associated mild to moderate flu/like symptoms. It is concluded that subcutaneous interferon alpha/2a, administered according to the current dosage and treatment schedule, is not effective as monotherapy in the treatment of refractory condylomata acuminata.Downloads
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