Altered expression of beta/2/microglobulin in basaloid proliferations overlying dermatofibromas.
DOI:
https://doi.org/10.2340/0001555572419421Abstract
The epidermis overlying 2/8% of dermatofibromas shows basaloid proliferations that are indistinguishable from superficial basal cell carcinoma. It is well established that basal cell carcinomas uniformly exhibit a strongly reduced expression of HLA class I molecules. Nineteen dermatofibromas with overlying basaloid proliferations were studied by immunohistochemistry using a monoclonal antibody against beta/2/microglobulin, the invariant chain of the HLA class I molecule. The basaloid proliferations exhibited the same strong reduction in expression of beta/2/microglobulin as demonstrated in basal cell carcinomas. We suggest that this phenomenon may represent a proliferative change induced by the mesenchymal cells of the underlying dermatofibroma.Downloads
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Published
1993-12-01
How to Cite
Rossen, K., Hou-Jensen, K., & Werdelin, O. (1993). Altered expression of beta/2/microglobulin in basaloid proliferations overlying dermatofibromas. Acta Dermato-Venereologica, 73(6), 419–421. https://doi.org/10.2340/0001555572419421
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