Interleukin-6 in normal skin and psoriasis.

Authors

  • A Castells-Rodellas
  • J V Castell
  • A Ramirez-Bosca
  • J F Nicolas
  • F Valcuende-Cavero
  • J Thivolet

DOI:

https://doi.org/10.2340/0001555572165168

Abstract

Interleukin-6 (IL-6 or BSF-2/IFN beta 2) is a component of normal human skin. IL-6 was immunologically detected in basal keratinocytes, endothelial cells and in a number of mononucleated cells and fibroblasts in normal skin and sudoriparous ducts. In psoriasis, intense labelling of the cytoplasm in the vicinity of keratinocyte membranes was detected in all epidermal layers and other skin appendages. The fact that this interleukin acts synergistically with respect to IL-1 and Tumour Necrosis Factor (TNF) strengthens the hypothesis whereby IL-6 may contribute via its receptor action to EGF function in modulating cell hyper-proliferation in psoriasis.

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Published

1992-01-01

How to Cite

Castells-Rodellas, A., Castell, J. V., Ramirez-Bosca, A., Nicolas, J. F., Valcuende-Cavero, F., & Thivolet, J. (1992). Interleukin-6 in normal skin and psoriasis. Acta Dermato-Venereologica, 72(3), 165–168. https://doi.org/10.2340/0001555572165168

Issue

Vol. 72 No. 3 (1992)

Section

Articles

License

All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.

Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.

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