Expression of the high affinity IgE-receptor on human Langerhans' cells. Elucidating the role of epidermal IgE in atopic eczema.
DOI:
https://doi.org/10.2340/0001555572271272Abstract
Epidermal Langerhans' cells have previously been shown to bear IgE molecules, particularly in atopic dermatitis skin. Using two highly specific antibodies against the antibody-binding chain of the high affinity IgE-receptor, 29C6 and 6F7, we here provide evidence that Langerhans' cells express this receptor in both normal skin (foreskin) and in lesional skin of patients with atopic and stasis eczema. A specific antibody against the low affinity IgE-receptor, Tü1, showed only a low expression of this receptor. This finding has important potential functional implications for the role of Langerhans' cells in transepidermal, IgE-mediated allergy.Downloads
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Published
1992-08-01
How to Cite
Haas, N., Hamann, K., Grabbe, J., Cremer, B., & Czarnetzki, B. M. (1992). Expression of the high affinity IgE-receptor on human Langerhans’ cells. Elucidating the role of epidermal IgE in atopic eczema. Acta Dermato-Venereologica, 72(4), 271–272. https://doi.org/10.2340/0001555572271272
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