Ultrastructural changes of the skin induced by human leukocyte elastase and cathepsin G.
DOI:
https://doi.org/10.2340/0001555571277282Abstract
Human neutrophil elastase and cathepsin G at a concentration of 10(-6) M were found to attack various substrates when normal skin biopsy specimens were incubated at 37 degrees C for 1 h with either of these enzymes. Elastase damaged primarily hemidesmosomes, leading to the epidermal cleavage from the dermis, whereas cathepsin G damaged the membrane structures. Both these neutral proteinases were highly specific to basal lamina of blood vessels. This indicates that neutrophil elastase and neutrophil cathepsin G may play different roles in various skin diseases related to enhanced activity and infiltration of neutrophils.Downloads
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Published
1991-01-01
How to Cite
Glinski, W., Kuligowski, M., Pierozynska-Dubowska, M., Glinska-Ferenz, M., & Jablonska, S. (1991). Ultrastructural changes of the skin induced by human leukocyte elastase and cathepsin G. Acta Dermato-Venereologica, 71(4), 277–282. https://doi.org/10.2340/0001555571277282
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