DNA interstrand crosslinks in normal human skin visualized by electron microscopy
DOI:
https://doi.org/10.2340/0001555558379382Abstract
Normal human skin was investigated for DNA interstrand crosslinks by a denaturation electron microscopic method. Skin biopsy materials from the thighs of 8 healthy volunteers were separated into epidermis and dermis. DNA from each layer was isolated, purified and studied in the electron microscope. The presence of DNA interstrand crosslinks in normal human skin was demonstrated. The number of crosslinked DNA molecules and the density of crosslinking within the molecules were determined. Crosslinks were found in 0.8% of the scored molecules and were located almost exclusively in epidermal DNA. The intramolecular density of crosslinking showed a wide range of variation in each volunteer and between the volunteers.Downloads
Download data is not yet available.
Downloads
Published
1978-09-01
How to Cite
Bohr, V., Wadskov, S., Søndergaard, J., & Lerche, A. (1978). DNA interstrand crosslinks in normal human skin visualized by electron microscopy. Acta Dermato-Venereologica, 58(5), 379–382. https://doi.org/10.2340/0001555558379382
Issue
Section
Articles
License
All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.
Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.
