The binding of 8-methoxypsoralen to nuclear DNA of UVA irradiated human fibroblasts in vitro

Authors

  • A Bredberg
  • B Lambert
  • G Swanbeck
  • M. Thyresson-Hök

DOI:

https://doi.org/10.2340/0001555557389391

Abstract

Human fibroblasts were exposed to tritium-labelled 8-methoxypsoralen (8-MOP) and longwave ultraviolet (UVA) light in vitro. The proportions of photochemically bound 8-MOP in the nucleus and cytoplasm were studied by autoradiography. The results show that UVA-irradiation of the cells in the presence of 8-MOP gives rise to a significant dose-dependent binding of 8-MOP in the cell nucleus.

Downloads

Download data is not yet available.

Downloads

Published

1977-09-01

How to Cite

Bredberg, A., Lambert, B., Swanbeck, G., & Thyresson-Hök, M. (1977). The binding of 8-methoxypsoralen to nuclear DNA of UVA irradiated human fibroblasts in vitro. Acta Dermato-Venereologica, 57(5), 389–391. https://doi.org/10.2340/0001555557389391

Issue

Section

Articles