Psoriasis and Dementia: A Cross-sectional Study of 121,801 Patients

Authors

  • Khalaf Kridin
  • Dennis Linder
  • Guy Shalom
  • Stefano Piaserico
  • Meir Babaev
  • Tamar Freud
  • Doron Comaneshter
  • Arnon D. Cohen

DOI:

https://doi.org/10.2340/00015555-3595

Keywords:

psoriasis, dementia, obesity, hypertension, diabetes, hyperlipidaemia, depression

Abstract

Data regarding the association between psoriasis and dementia are inconclusive. The aim of this study was to evaluate this association in the database of Clalit Health Services, Israel. A comparative analysis for the association between psoriasis, dementia and its risk factors was performed for the entire study population and in the subgroup of patients with moderate-to-severe psoriasis. The study included 121,801 patients with psoriasis, of whom 16,947 were diagnosed with moderate-to-severe psoriasis, and 121,802 controls. Psoriasis was associated with a lower prevalence of dementia relative to control subjects (1.6% vs 1.8%; odds ratio (OR) 0.85; 95% confidence interval (95% CI) 0.80?0.91; p?<?0.001). Multivariate analysis adjusting for demographic variables, cardiovascular-related risk factors, and healthcare utilization demonstrated a significant inverse association between psoriasis and dementia in the entire study population (adjusted OR 0.86; 95% CI 0.76?0.96; p?=?0.009), but not in the subgroup of patients with moderate-to-severe psoriasis (adjusted OR 0.91; 95% CI 0.81?1.02; p?=?0.113). In conclusion, these data support the hypothesis that psoriasis is inversely associated with dementia.

Downloads

Download data is not yet available.

Published

2020-08-19

How to Cite

Kridin, K., Linder, D., Shalom, G., Piaserico, S., Babaev, M., Freud, T., … D. Cohen, A. (2020). Psoriasis and Dementia: A Cross-sectional Study of 121,801 Patients. Acta Dermato-Venereologica, 100(15), 1–5. https://doi.org/10.2340/00015555-3595

Issue

Section

Articles