Development of Nodular Lesions after Dupilumab Therapy in Erythrodermic Mycosis Fungoides with Interleukin-13 Receptor alpha2 Expression

Authors

  • Mina Hashimoto
  • Tomomitsu Miyagaki Department of Dermatology, St Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa 216-8511, Japan
  • Reo Komaki
  • Sora Takeuchi
  • Takafumi Kadono

DOI:

https://doi.org/10.2340/actadv.v102.2234

Keywords:

erythroderma, mycosis fungoides, dupilumab, progression, IL-13 receptor alpha 2

Abstract

Abstract is missing (Short communication)

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References

Miyagaki T, Sugaya M. Immunological milieu in mycosis fungoides and Sézary syndrome. J Dermatol 2014; 41: 11-18.

https://doi.org/10.1111/1346-8138.12305

Sugaya M. Is blocking IL-4 receptor alpha beneficial for patients with mycosis fungoides or Sézary syndrome? J Dermatol 2021; 48: e225-226.

https://doi.org/10.1111/1346-8138.15834

Elston DM. Dupilumab and cutaneous T-cell lymphoma. J Am Acad Dermatol 2020; 83: 33-34.

https://doi.org/10.1016/j.jaad.2020.03.051

Suzuki A, Leland P, Joshi BH, Puri RK. Targeting of IL-4 and IL-13 receptors for cancer therapy. Cytokine 2015; 75: 79-88.

https://doi.org/10.1016/j.cyto.2015.05.026

Geskin LJ, Viragova S, Stolz DB, Fuschiotti P. Interleukin-13 is overexpressed in cutaneous T-cell lymphoma cells and regulates their proliferation. Blood 2015; 125: 2798-2805.

https://doi.org/10.1182/blood-2014-07-590398

Shimamura T, Fujisawa T, Husain SR, Joshi B, Puri RK. Interleukin 13 mediates signal transduction through interleukin 13 receptor alpha2 in pancreatic ductal adenocarcinoma: role of IL-13 pseudomonas exotoxin in pancreatic cancer therapy. Clin Cancer Res 2010; 16: 577-586.

https://doi.org/10.1158/1078-0432.CCR-09-2015

Fujisawa T, Joshi BH, Puri RK. IL-13 regulates cancer invasion and metastasis through IL-13Rα2 via ERK/AP-1 pathway in mouse model of human ovarian cancer. Int J Cancer 2012; 131: 344-356.

https://doi.org/10.1002/ijc.26366

Tu M, Wange W, Cai L, Zhu P, Gao Z, Zheng W. IL-13 receptor alpha2 stimulates human glioma cell growth and metastasis through the Src/PI3K/Akt/mTOR signaling pathway. Tumour Biol 2016; 37: 14701-14709.

https://doi.org/10.1007/s13277-016-5346-x

Fichtner-Feigl S, Strober W, Kawakami K, Puri RK, Kitani A. IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis. Nat Med 2006; 12: 99-106.

https://doi.org/10.1038/nm1332

Shaulian E, Karin M. AP-1 in cell proliferation and survival. Oncogene 2001; 20: 2390-2400.

https://doi.org/10.1038/sj.onc.1204383

Lazaridou I, Ram-Wolff C, Bouaziz JD, Bégon E, Battistella M, Rivet J, et al. Dupilumab Treatment in Two Patients with Cutaneous T-cell Lymphomas. Acta Derm Venereol 2020; 100: adv00271.

https://doi.org/10.2340/00015555-3576

Mollanazar NK, Savage KT, Pousti BT, Jariwala N, Del Guzzo C, Haun P, et al. Cutaneous T-cell lymphoma and concomitant atopic dermatitis responding to dupilumab. Cutis 2020; 106: 131-132.

https://doi.org/10.12788/cutis.0066

Steck O, Bertschi NL, Luther F, van den Berg J, Winkel DJ, Holbro A, et al. Rapid and sustained control of itch and reduction in Th2 bias by dupilumab in a patient with Sézary syndrome. J Eur Acad Dermatol Venereol 2021; 35: 1331-1337.

https://doi.org/10.1111/jdv.17001

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Published

2022-08-24

How to Cite

Hashimoto, M., Miyagaki, T., Komaki, R., Takeuchi, S., & Kadono, T. (2022). Development of Nodular Lesions after Dupilumab Therapy in Erythrodermic Mycosis Fungoides with Interleukin-13 Receptor alpha2 Expression. Acta Dermato-Venereologica, 102, adv00766. https://doi.org/10.2340/actadv.v102.2234

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