Altered Maturation of the Skin Microbiome in Infants with Atopic Dermatitis

Authors

  • Caroline M. Olesen Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark
  • Maja-Lisa Clausen Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark
  • Tove Agner Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark
  • Maria Asplund The Globe Institute, Faculty of Health, University of Copenhagen, Copenhagen, Denmark
  • Linett Rasmussen The Globe Institute, Faculty of Health, University of Copenhagen, Copenhagen, Denmark
  • Yasemin T. Yüksel Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark
  • Paal S. Andersen Department of Bacteria, Parasites and Fungi, Statens Serum Institute, Copenhagen, Denmark
  • Thomas Litman Department of Immunology and Microbiology, LEO Foundation Skin Immunology Research Center, University of Copenhagen, Copenhagen, Denmark
  • Anders J. Hansen The Globe Institute, Faculty of Health, University of Copenhagen, Copenhagen, Denmark
  • Christopher J. Barnes The Globe Institute, Faculty of Health, University of Copenhagen, Copenhagen, Denmark

DOI:

https://doi.org/10.2340/actadv.v102.2275

Keywords:

Atopic dermatitis, Skin microbiome, Infant

Abstract

The aim of this study was to investigate the early-life development of the skin microbiome in atopic dermatitis. Nineteen infants with atopic dermatitis and 19 healthy infants were evaluated 3 times, at 3 months intervals, within the first 30 months of life. Tape-strips were collected from volar forearms, cheeks, and eczema lesions, and the skin microbiome was assessed by 16S rRNA sequencing. Both the community structure and richness of the skin microbiome of infants with atopic dermatitis differed significantly from that of healthy infants, with greater richness in healthy infants. For infants with atopic dermatitis, the community composition was not dominated by Staphylococci. For healthy infants, community composition and richness correlated significantly with age, while such a pattern was not revealed in infants with atopic dermatitis. This suggests a slower maturation of the skin microbiome in atopic dermatitis, which precedes the staphylococcal predominance observed in older children and adults.

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Published

2022-11-21

How to Cite

Olesen, C. M., Clausen, M.-L., Agner, T., Asplund, M., Rasmussen, L., Yüksel, Y. T., Andersen, P. S., Litman, T., Hansen, A. J., & Barnes, C. J. (2022). Altered Maturation of the Skin Microbiome in Infants with Atopic Dermatitis. Acta Dermato-Venereologica, 102, adv00817. https://doi.org/10.2340/actadv.v102.2275

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Vol. 102 (2022)

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Copyright (c) 2022 Caroline M. Olesen, Maja-Lisa Clausen, Tove Agner, Maria Asplund, Linett Rasmussen, Yasemin T. Yüksel, Paal S. Andersen, Thomas Litman, Anders J. Hansen, Christopher J. Barnes

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