A Retrospective Cohort Study on the Comorbidity in 19,264 Chinese Patients of Different Ages with Urticaria
DOI:
https://doi.org/10.2340/actadv.v104.24050Keywords:
Urticaria, Comorbidity, Chronic Urticaria, Acute Urticaria, Medication, Charlson Comorbidity IndexAbstract
To examine the prevalence of comorbidities in Chinese urticaria patients and assess medication use patterns across different ages (6–11 years, 12–17 years, above 18 years), a retrospective cohort study was performed in 192,647 urticaria patients within the Health Database. After 1:1 propensity score matching, 166,921 people were divided into the urticaria group and the control group, and the follow-up data were collected within 2 years. During the 12-month and 24-month follow-up period, significant comorbidities identified included allergic rhinitis and asthma, with distinct patterns observed across age groups. Chronic urticaria patients often have complications, such as allergic rhinitis, upper respiratory infection, oropharyngeal infection, and dental caries. The study underscores the need for age-specific treatment strategies in urticaria management.
Downloads
References
Zuberbier T, Abdul Latiff AH, Abuzakouk M, Aquilina S, Asero R, Baker D, et al. The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria. Allergy 2022; 77: 734-766.
https://doi.org/10.1111/all.15090 DOI: https://doi.org/10.1111/all.15090
Zuberbier T, Aberer W, Asero R, Abdul Latiff AH, Baker D, Ballmer-Weber B, et al. The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Allergy 2018; 73: 1393-1414.
https://doi.org/10.1111/all.13397 DOI: https://doi.org/10.1111/all.13397
XU J. Guideline for diagnosis and treatment of urticaria in China (2018). Chin J Dermatol 2019: 1-5.
XU J. Guideline for diagnosis and treatment of urticaria in China (2022). Chin J Dermatol 2022; 55: 1041-1049.
Guo C, Saltoun C. Urticaria and angioedema. Allergy Asthma Proc 2019; 40: 437-440.
https://doi.org/10.2500/aap.2019.40.4266 DOI: https://doi.org/10.2500/aap.2019.40.4266
He L, Yi W, Huang X, Long H, Lu Q. Chronic urticaria: advances in understanding of the disease and clinical management. Clin Rev Allergy Immunol 2021; 61: 424-448.
https://doi.org/10.1007/s12016-021-08886-x DOI: https://doi.org/10.1007/s12016-021-08886-x
Sánchez-Borges M, Ansotegui IJ, Baiardini I, Bernstein J, Canonica GW, Ebisawa M, et al. The challenges of chronic urticaria part 1: Epidemiology, immunopathogenesis, comorbidities, quality of life, and management. World Allergy Organ J 2021; 14: 100533.
https://doi.org/10.1016/j.waojou.2021.100533 DOI: https://doi.org/10.1016/j.waojou.2021.100533
Kim BR, Yang S, Choi JW, Choi CW, Youn SW. Epidemiology and comorbidities of patients with chronic urticaria in Korea: A nationwide population-based study. J Dermatol 2018; 45: 10-16.
https://doi.org/10.1111/1346-8138.14075 DOI: https://doi.org/10.1111/1346-8138.14075
Staubach P, Dechene M, Metz M, Magerl M, Siebenhaar F, Weller K, et al. High prevalence of mental disorders and emotional distress in patients with chronic spontaneous urticaria. Acta Derm Venereol 2011; 91: 557-561.
https://doi.org/10.2340/00015555-1109 DOI: https://doi.org/10.2340/00015555-1109
Kolkhir P, Metz M, Altrichter S, Maurer M. Comorbidity of chronic spontaneous urticaria and autoimmune thyroid diseases: a systematic review. Allergy 2017; 72: 1440-1460.
https://doi.org/10.1111/all.13182 DOI: https://doi.org/10.1111/all.13182
Ghazanfar MN, Kibsgaard L, Thomsen SF, Vestergaard C. Risk of comorbidities in patients diagnosed with chronic urticaria: a nationwide registry-study. World Allergy Organ J 2020; 13: 100097.
https://doi.org/10.1016/j.waojou.2019.100097 DOI: https://doi.org/10.1016/j.waojou.2019.100097
Chu CY, Cho YT, Jiang JH, Lin EI, Tang CH. Epidemiology and comorbidities of patients with chronic urticaria in Taiwan: a nationwide population-based study. J Dermatol Sci 2017; 88: 192-198.
https://doi.org/10.1016/j.jdermsci.2017.07.006 DOI: https://doi.org/10.1016/j.jdermsci.2017.07.006
Konstantinou GN, Konstantinou GN. Psychiatric comorbidity in chronic urticaria patients: a systematic review and meta-analysis. Clin Transl Allergy 2019; 9: 42.
https://doi.org/10.1186/s13601-019-0278-3 DOI: https://doi.org/10.1186/s13601-019-0278-3
Cornillier H, Giraudeau B, Munck S, Hacard F, Jonville-Bera AP, d'Acremont G, et al. Chronic spontaneous urticaria in children: a systematic review on interventions and comorbidities. Pediatr Allergy Immunol 2018; 29: 303-310.
https://doi.org/10.1111/pai.12870 DOI: https://doi.org/10.1111/pai.12870
Mazur M, Czarnobilska M, Czarnobilska E. Prevalence and potential risk factors of urticaria in the Polish population of children and adolescents. Postepy Dermatol Alergol 2020; 37: 785-789.
https://doi.org/10.5114/ada.2020.100489 DOI: https://doi.org/10.5114/ada.2020.100489
Arik Yilmaz E, Karaatmaca B, Sackesen C, Sahiner UM, Cavkaytar O, Sekerel BE, et al. Parasitic infections in children with chronic spontaneous urticaria. Int Arch Allergy Immunol 2016; 171: 130-135.
https://doi.org/10.1159/000450953 DOI: https://doi.org/10.1159/000450953
Kolkhir P, Balakirski G, Merk HF, Olisova O, Maurer M. Chronic spontaneous urticaria and internal parasites: a systematic review. Allergy 2016; 71: 308-322.
https://doi.org/10.1111/all.12818 DOI: https://doi.org/10.1111/all.12818
Qiu H, Zheng R, Wang X, Chen Z, Feng P, Huang X, et al. Using the internet big data to investigate the epidemiological characteristics of allergic rhinitis and allergic conjunctivitis. Risk Manag Healthc Policy 2021; 14: 1833-1841.
https://doi.org/10.2147/RMHP.S307247 DOI: https://doi.org/10.2147/RMHP.S307247
Ma T, Chen Y, Pang Y, Wang X, Dai D, Zhuang Y, et al. Prevalence and risk factors of allergic rhinitis and asthma in the southern edge of the plateau grassland region of northern China: a cross-sectional study. World Allergy Organ J 2021; 14: 100537.
https://doi.org/10.1016/j.waojou.2021.100537 DOI: https://doi.org/10.1016/j.waojou.2021.100537
Weidinger S, Novak N. seminar atopic dermatitis. Lancet 2016; 387: 1109-1122.
https://doi.org/10.1016/S0140-6736(15)00149-X DOI: https://doi.org/10.1016/S0140-6736(15)00149-X
Gu H, You LP, Liu YS. Survey on the prevalence of childhood atopic dermatitis in ten cities of China. Chin J Dermatology 2004; 37: 29-31.
Guo Y, Li P, Tang J, Han X, Zou X, Xu G, et al. Prevalence of atopic dermatitis in Chinese children aged 1-7 ys. Sci Rep 2016; 6: 29751.
https://doi.org/10.1038/srep29751 DOI: https://doi.org/10.1038/srep29751
Yadav MK, Rishi JP, Nijawan S. Chronic urticaria and helicobacter pylori. Indian J Med Sci 2008; 62: 157-162.
https://doi.org/10.4103/0019-5359.40579 DOI: https://doi.org/10.4103/0019-5359.40579
Mogaddam MR, Yazdanbod A, Ardabili NS, Maleki N, Isazadeh S. Relationship between Helicobacter pylori and idiopathic chronic urticaria: effectiveness of Helicobacter pylori eradication. Postepy Dermatol Alergol 2015; 32: 15-20.
https://doi.org/10.5114/pdia.2015.48729 DOI: https://doi.org/10.5114/pdia.2015.48729
Additional Files
Published
How to Cite
License
Copyright (c) 2024 Meng Xiao, Xinmei Zhang, Afei Guo, Kaiyue Zhang, Qian Zhao, Liyun Fan, Lu Xue, Junyan Zhang, Shuping Hou, Huiping Wang
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.
Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.