Topical Minoxidil Rejuvenates Hair Follicles from Men with Androgenetic Alopecia in Vivo

Authors

  • Assaf A. Zeltzer Plastic & Reconstructive Surgery Department, Rambam Health Care Campus, Haifa, Israel
  • Aviad Keren Skin Research Laboratory, Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel
  • Ralf Paus Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA; CUTANEON, Hamburg & Berlin, Germany
  • Amos Gilhar Skin Research Laboratory, Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel https://orcid.org/0000-0002-4267-2986

DOI:

https://doi.org/10.2340/actadv.v104.24213

Keywords:

Minoxidil, hair follicle, Aging, Rejuvination, SCID mice

Abstract

Abstract is missing (Short communication)

Downloads

Download data is not yet available.

References

Gupta AK, Carviel J. Androgenetic alopecia: a review. Skin Appendage Disorders 2019; 5: 215-224.

https://doi.org/10.1159/000501940 DOI: https://doi.org/10.1159/000501940

Chew EGY, Lim TC, Leong MF, Liu X, Sia YY, Leong ST, et al. Observations that suggest a contribution of altered dermal papilla mitochondrial function to androgenetic alopecia. Exp Dermatol 2022; 31: 906-917.

https://doi.org/10.1111/exd.14536 DOI: https://doi.org/10.1111/exd.14536

Matsumura H, Mohri Y, Binh NT, Morinaga H, Fukuda M, Ito M, et al. Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis. Science 2016; 351: aad4395.

https://doi.org/10.1126/science.aad4395

Haslam IS, Jadkauskaite L, Szabó IL, Staege S, Hesebeck-Brinckmann J, Jenkins G, et al. Oxidative damage control in a human (mini-) organ: Nrf2 activation protects against oxidative stress-induced hair growth inhibition. J Invest Dermatol 2017; 137: 295-304.

https://doi.org/10.1016/j.jid.2016.08.035 DOI: https://doi.org/10.1016/j.jid.2016.08.035

Chew EGY, Tan JHJ, Bahta AW, Ho BS, Liu X, Lim TC, et al. Differential expression between human dermal papilla cells from balding and non-balding scalps reveals new candidate genes for androgenetic alopecia. J Invest Dermatol 2016; 136: 1559-1567.

https://doi.org/10.1016/j.jid.2016.03.032 DOI: https://doi.org/10.1016/j.jid.2016.03.032

Yano K, Brown LF, Detmar M. Control of hair growth and follicle size by VEGF-mediated angiogenesis. J Clin Invest 2001; 107: 409-417.

https://doi.org/10.1172/JCI11317 DOI: https://doi.org/10.1172/JCI11317

Keren A, Bertolini M, Keren Y, Ullmann Y, Paus R, Gilhar A. Human organ rejuvenation by VEGF-A: lessons from the skin. Sci Adv 2022; 8: eabm6756.

https://doi.org/10.1126/sciadv.abm6756 DOI: https://doi.org/10.1126/sciadv.abm6756

Yum S, Jeong S, Kim D, Lee S, Kim W, Yoo JW, et al. Minoxidil induction of VEGF Is mediated by inhibition of HIF-prolyl hydroxylase. Int J Mol Sci 2017; 19: 53.

https://doi.org/10.3390/ijms19010053 DOI: https://doi.org/10.3390/ijms19010053

Jadkauskaite L, Coulombe PA, Schäfer M, Dinkova-Kostova AT, Paus R, Haslam IS. Oxidative stress management in the hair follicle: could targeting NRF2 counter age-related hair disorders and beyond? Bioessays 2017; 39.

https://doi.org/10.1002/bies.201700029 DOI: https://doi.org/10.1002/bies.201700029

Jadkauskaite L, Bahri R, Farjo N, Farjo B, Jenkins G, Bhogal R, et al. Nuclear factor (erythroid-derived 2)-like-2 pathway modulates substance P-induced human mast cell activation and degranulation in the hair follicle. J Allergy Clin Immunol 2018; 142: 1331-1333.

https://doi.org/10.1016/j.jaci.2018.04.039 DOI: https://doi.org/10.1016/j.jaci.2018.04.039

Gilhar A, Keren A, Ullmann Y, Wu J, Paus R. Effect of minoxidil formulations on human scalp skin xenotransplants on SCID mice: a novel pre-clinical in vivo assay for androgenetic alopecia research. Exp Dermatol 2022; 31: 980-982.

https://doi.org/10.1111/exd.14523 DOI: https://doi.org/10.1111/exd.14523

Laufer Britva R, Keren A, Ginzburg A, Ullmann Y, Paus R, Gilhar A. Evidence from a humanized mouse model of androgenetic alopecia that platelet-rich plasma stimulates hair regrowth, hair shaft diameter and vellus-to-terminal hair reconversion in vivo. Br J Dermatol 2021; 185: 644-646.

https://doi.org/10.1111/bjd.20084 DOI: https://doi.org/10.1111/bjd.20084

Bulbiankova D, Díaz-Puertas R, Álvarez-Martínez FJ, Herranz-López M, Barrajón-Catalán E, Micol V. Hallmarks and biomarkers of skin senescence: an updated review of skin senotherapeutics. Antioxidants (Basel) 2023; 12: 444.

https://doi.org/10.3390/antiox12020444 DOI: https://doi.org/10.3390/antiox12020444

Wang AS, Dreesen O. Biomarkers of cellular senescence and skin aging. Front Genet 2018; 9: 247.

https://doi.org/10.3389/fgene.2018.00247 DOI: https://doi.org/10.3389/fgene.2018.00247

Suzuki T, Chéret J, Scala FD, Akhundlu A, Gherardini J, Demetrius DL, et al. mTORC1 activity negatively regulates human hair follicle growth and pigmentation. EMBO Rep 2023; 24: e56574.

https://doi.org/10.15252/embr.202256574 DOI: https://doi.org/10.15252/embr.202256574

Matsumura H, Mohri Y, Binh NT, Morinaga H, Fukuda M, Ito M, et al. Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis. Science 2016; 351: aad4395.

https://doi.org/10.1126/science.aad4395 DOI: https://doi.org/10.1126/science.aad4395

Abu Shelbayeh O, Arroum T, Morris S, Busch KB. PGC-1α is a master regulator of mitochondrial lifecycle and ROS stress response. Antioxidants (Basel) 2023; 12: 1075.

https://doi.org/10.3390/antiox12051075 DOI: https://doi.org/10.3390/antiox12051075

Vidali S, Knuever J, Lerchner J, Giesen M, Bíró T, Klinger M, et al. Hypothalamic-pituitary-thyroid axis hormones stimulate mitochondrial function and biogenesis in human hair follicles. J Invest Dermatol 2014; 134: 33-42.

https://doi.org/10.1038/jid.2013.286 DOI: https://doi.org/10.1038/jid.2013.286

Ryter SW. Heme oxygenase-1: an anti-inflammatory effector in cardiovascular, lung, and related metabolic disorders. Antioxidants (Basel) 2022; 11: 555.

https://doi.org/10.3390/antiox11030555 DOI: https://doi.org/10.3390/antiox11030555

Sreedhar A, Aguilera-Aguirre L, Singh KK. Mitochondria in skin health, aging, and disease. Cell Death Dis 2020; 11: 444.

https://doi.org/10.1038/s41419-020-2649-z DOI: https://doi.org/10.1038/s41419-020-2649-z

Randolph M, Tosti A. Oral minoxidil treatment for hair loss: a review of efficacy and safety. J Am Acad Dermatol 2021; 84: 737-746.

https://doi.org/10.1016/j.jaad.2020.06.1009 DOI: https://doi.org/10.1016/j.jaad.2020.06.1009

Ntshingila S, Oputu O, Arowolo AT, Khumalo NP. Androgenetic alopecia: an update. JAAD Int 2023; 13: 150-158.

https://doi.org/10.1016/j.jdin.2023.07.005 DOI: https://doi.org/10.1016/j.jdin.2023.07.005

Piccini I, Brunken L, Chéret J, Ghatak S, Ramot Y, Alam M, et al. Peroxisome proliferator-activated receptor-γ signalling protects hair follicle stem cells from chemotherapy-induced apoptosis and epithelial-mesenchymal transition. Br J Dermatol 2022; 186: 129-141.

https://doi.org/10.1111/bjd.20745 DOI: https://doi.org/10.1111/bjd.20745

Published

2024-06-11

How to Cite

Zeltzer, A. A., Keren, A., Paus, R., & Gilhar, A. (2024). Topical Minoxidil Rejuvenates Hair Follicles from Men with Androgenetic Alopecia in Vivo. Acta Dermato-Venereologica, 104, adv24213. https://doi.org/10.2340/actadv.v104.24213