Topical Application of Glycerol Increases Penetration Depth of Optical Coherence Tomography in Diagnosis of Basal Cell Carcinoma
DOI:
https://doi.org/10.2340/00015555-3811Keywords:
optical coherence tomography, basal cell carcinoma, optical clearing agentsAbstract
Optical coherence tomography is a non-invasive imaging technique that enables high-resolution in vivo imaging of skin. Although optical coherence tomography is promising for diagnosing basal cell carcinoma, its limited penetration depth may impede basal cell carcinoma subtyping. This study evaluated whether topical application of glycerol can increase penetration depth and improve the image quality and visibility of characteristic features of basal cell carcinoma. A total of 61 patients with a total of 72 basal cell carcinomas were included. Optical coherence tomography scans were obtained before and after application of an 85% glycerol solution. The mean penetration depth of each optical coherence tomography scan was acquired by automatically tracing both skin surface and the point of signal loss using a custom-made MATLAB program. Mean ± standard deviation penetration depth increased from 883 ± 108 to 904 ± 88 µm before and after glycerol application, respectively (p = 0.005). Topical application of glycerol leads to a significant 2.4% increase in penetration depth. However, no significant differences in image quality and visibility of basal cell carcinoma features were found.
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References
Flohil SC, de Vries E, Neumann HA, Coebergh JW, Nijsten T. Incidence, prevalence and future trends of primary basal cell carcinoma in the Netherlands. Acta Derm Venereol 2011; 91: 24-30.
https://doi.org/10.2340/00015555-1009
NVDV. Multi-disciplinary evidence-based guideline basal cel carcinoma. [accessed december 2020] Available from: www.oncoline.nl. Utrecht, 2015.
Peris K, Fargnoli MC, Garbe C, Kaufmann R, Bastholt L, Seguin NB, et al. Diagnosis and treatment of basal cell carcinoma: European consensus-based interdisciplinary guidelines. Eur J Cancer 2019; 118: 10-34.
https://doi.org/10.1016/j.ejca.2019.06.003
Ferrante di Ruffano L, Dinnes J, Deeks JJ, Chuchu N, Bayliss SE, Davenport C, et al. Optical coherence tomography for diagnosing skin cancer in adults. Cochrane Database Syst Rev 2018; 12: CD013189.
https://doi.org/10.1002/14651858.CD013187
Sinx KAE, van Loo E, Tonk EHJ, Kelleners-Smeets NWJ, Winnepenninckx VJL, Nelemans PJ, et al. Optical coherence tomography for noninvasive diagnosis and subtyping of basal cell carcinoma: a prospective cohort study. J Invest Dermatol 2020; 140: 1962-1967.
https://doi.org/10.1016/j.jid.2020.01.034
Ulrich M, von Braunmuehl T, Kurzen H, Dirschka T, Kellner C, Sattler E, et al. The sensitivity and specificity of optical coherence tomography for the assisted diagnosis of nonpigmented basal cell carcinoma: an observational study. Br J Dermatol 2015; 173: 428-435.
https://doi.org/10.1111/bjd.13853
Mogensen M, Joergensen TM, Nurnberg BM, Morsy HA, Thomsen JB, Thrane L, et al. Assessment of optical coherence tomography imaging in the diagnosis of non-melanoma skin cancer and benign lesions versus normal skin: observerblinded evaluation by dermatologists and pathologists. Dermatol Surg 2009; 35: 965-972.
https://doi.org/10.1111/j.1524-4725.2009.01164.x
Pyne JH, Myint E, Barr EM, Clark SP, Hou R. Basal cell carcinoma: variation in invasion depth by subtype, sex, and anatomic site in 4,565 cases. Dermatol Pract Concept 2018; 8: 314-319.
https://doi.org/10.5826/dpc.0804a13
Shan H, Liang Y, Wang J, Li Y. Study on application of optical clearing technique in skin diseases. J Biomed Opt 2012; 17: 115003.
https://doi.org/10.1117/1.JBO.17.11.115003
Wang B, Wang HW, Guo H, Anderson E, Tang Q, Wu T, et al. Optical coherence tomography and computer-aided diagnosis of a murine model of chronic kidney disease. J Biomed Opt 2017; 22: 1-11.
https://doi.org/10.1117/1.JBO.22.12.121706
Liew YM, McLaughlin RA, Wood FM, Sampson DD. Reduction of image artifacts in three-dimensional optical coherence tomography of skin in vivo. J Biomed Opt 2011; 16: 116018.
https://doi.org/10.1117/1.3652710
Tycho AAP, Thrane L, Jemec GBE. Optical coherence tomography in dermatology. In: Serup J, Jemec GBE, Grove GL, editors. Handbook of non-invasive methods and the Skin, 2nd edn. Boca Raton, Florida: Taylor and Francis Group; 2006, p. 257-266.
https://doi.org/10.3109/9781420003307-38
Fluhr JW, Darlenski R, Surber C. Glycerol and the skin: holistic approach to its origin and functions. Br J Dermatol 2008; 159: 23-34.
https://doi.org/10.1111/j.1365-2133.2008.08643.x
Welzel J, Reinhardt C, Lankenau E, Winter C, Wolff HH. Changes in function and morphology of normal human skin: evaluation using optical coherence tomography. Br J Dermatol 2004; 150: 220-225.
https://doi.org/10.1111/j.1365-2133.2004.05810.x
Hussain AA, Themstrup L, Jemec GB. Optical coherence tomography in the diagnosis of basal cell carcinoma. Arch Dermatol Res 2015; 307: 1-10.
https://doi.org/10.1007/s00403-014-1498-y
Holmes J, von Braunmuhl T, Berking C, Sattler E, Ulrich M, Reinhold U, et al. Optical coherence tomography of basal cell carcinoma: influence of location, subtype, observer variability and image quality on diagnostic performance. Br J Dermatol 2018; 178: 1102-1110.
https://doi.org/10.1111/bjd.16154
Cheng HM, Guitera P. Systematic review of optical coherence tomography usage in the diagnosis and management of basal cell carcinoma. Br J Dermatol 2015; 173: 1371-1380.
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Copyright (c) 2021 Fieke Adan, Ellen M.M. Oyen, Robert J. Holtackers, Eva van Loo, Gert-Jan Dermont, Nicole W.J. Kelleners-Smeets, Patty J. Nelemans, Klara Mosterd
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