Real-life Effectiveness and Safety of Risankizumab in Moderate-to-severe Plaque Psoriasis: A 40-week Multicentric Retrospective Study

Authors

  • Riccardo G. Borroni Department of Biomedical Sciences, Humanitas University, Dermatology Unit, Humanitas Clinical and Research Center – IRCCS, Via Rita Levi Montalcini, 4, IT-20090 Pieve Emanuele MI, Italy
  • Piergiorgio Malagoli
  • Luigi Gargiulo
  • Mario Valenti
  • Giulia Pavia
  • Paola Facheris
  • Emanuela Morenghi
  • Isotta Giunipero di Corteranzo
  • Alessandra Narcisi
  • Michela Ortoncelli
  • Paolo Dapavo
  • Antonio Costanzo

DOI:

https://doi.org/10.2340/actadv.v101.283

Keywords:

risankizumab, psoriasis, real-life

Abstract

Risankizumab is a humanized monoclonal antibody that binds the p19 subunit of interleukin-23. It is approved for treatment of moderate-severe chronic plaque psoriasis. This retrospective study included 66 consecutive adults with moderate-to-severe psoriasis vulgaris treated with risankizumab in monotherapy up to week 40 in a “real-life” setting. At week 40, 98.7%, 85.7% and 62.3% of patients achieved a Psoriasis Area and Severity Index (PASI) reduction ≥ 75% (PASI 75), PASI 90 and PASI 100, respectively. Patients who had not responded to 2 or more previous biologic treatments were significantly less likely to achieve PASI 75/90 at week 16 and PASI 90/100 at week 40 compared with those who had been previously treated with only 1 biologic, and compared with those treated with risankizumab as a first-line biologic. Increasing body mass index decreased the chances of reaching PASI 90 at week 40. No significant safety findings were recorded throughout the study, and none of the patients had to interrupt the treatment. These data suggest that the efficacy of risankizumab for plaque psoriasis in “real-life” clinical practice could differ from pivotal clinical trials data.

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Published

2021-11-30

How to Cite

Borroni, R. G., Malagoli, P., Gargiulo , L., Valenti, M., Pavia, G., Facheris, P., Morenghi, E., di Corteranzo, I. G., Narcisi, A., Ortoncelli, M., Dapavo, P., & Costanzo, A. (2021). Real-life Effectiveness and Safety of Risankizumab in Moderate-to-severe Plaque Psoriasis: A 40-week Multicentric Retrospective Study. Acta Dermato-Venereologica, 101(11), adv00605. https://doi.org/10.2340/actadv.v101.283