Modifiable Risk-factors for Keratinocyte Cancers in Australia: A Case-control Study

Authors

  • Lina Maria Serna-Higuita
  • Simone L. Harrison
  • Petra Buttner
  • Margaret Glasby
  • Beverly A. Raasch
  • Angelika Iftner
  • Claus Garbe
  • Peter Martus
  • Thomas Iftner

DOI:

https://doi.org/10.2340/00015555-3107

Keywords:

risk factor, keratinocyte cancer, sunlight, sunscreen, basal cell cancer, squamous cell cancer

Abstract

Keratinocyte cancer is the most common malignancy in Caucasians. The aim of this study was to investigate risk-factors responsible for development of keratinocyte cancer in Australia. A case-control study was conducted, including 112 cases of squamous cell carcinoma (SCC), 95 cases of basal cell carcinoma (BCC) and 122 controls. Freckling during adolescence (SCC: odds ratio (OR) 1.04, p?<?0.01; BCC: OR 1.05, p?<?0.01), propensity to sunburn (SCC: OR 2.75, p?=?0.01, BCC: OR 2.68 p?=?0.01) and high cumulative sun-exposure (SCC: OR 2.43, p?=?0.04; BCC: OR 2.36 p?=?0.04) were independent risk-factors for both SCC and BCC. This study provides further evidence that a sun-sensitive phenotype and excessive sun-exposure during adulthood contribute to the risk of developing keratinocyte cancer. Wearing a hat, long-sleeved shirts, and sunscreen did not significantly reduce the risk of keratinocyte cancer in this study.

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Published

2019-02-07

How to Cite

Serna-Higuita, L. M., Harrison, S. L., Buttner, P., Glasby, M., Raasch, B. A., Iftner, A., Garbe, C., Martus, P., & Iftner, T. (2019). Modifiable Risk-factors for Keratinocyte Cancers in Australia: A Case-control Study. Acta Dermato-Venereologica, 99(4), 404–411. https://doi.org/10.2340/00015555-3107

Issue

Vol. 99 No. 4 (2019): April

Section

Articles

License

Copyright (c) 2019 Lina Maria Serna-Higuita, Simone L. Harrison, Petra Buttner, Margaret Glasby, Beverly A. Raasch, Angelika Iftner, Claus Garbe, Peter Martus, Thomas Iftner

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.

Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.

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