Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical Trial
DOI:
https://doi.org/10.2340/00015555-3305Keywords:
psoriasis, dermatology, probiotic, microbiome, microbiotaAbstract
The aim of this 12-week randomized, double-blind, placebo-controlled trial was to determine the efficacy and safety of a probiotic mixture in the reduction of psoriasis severity. Ninety 18?70-year-old adults with plaque psoriasis were randomized into probiotic and placebo groups. At 12-week follow-up, 66.7% of patients in the probiotic group and 41.9% in the placebo group showed a reduction in Psoriasis Area and Severity Index of at least 75% (p?<?0.05). A clinically relevant difference was observed in Physician Global Assessment index: 48.9% in the probiotic group achieved a score of 0 or 1, compared with 30.2% in the placebo group. The results of follow-up 6 months after the end of the study showed a lower risk of relapse after the intake of the probiotic mixture. Analysis of gut microbiota confirmed the efficacy of the probiotic in modulation of the microbiota composition.Downloads
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Copyright (c) 2019 Vicente Navarro-López, Asunción Martínez-Andrés, Ana Ramírez-Boscá, Beatriz Ruzafa-Costas, Eva Núñez-Delegido, Miguel A. Carrión-Gutiérrez, David Prieto-Merino, Francisco Codoñer-Cortés, Daniel Ramón-Vidal, Salvador Genovés-Martínez, Empar Chenoll-Cuadros, José M. Pérez-Orquín, José A. Picó-Monllor, Sara Chumillas-Lidón
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