Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical Trial

Authors

  • Vicente Navarro-López
  • Asunción Martínez-Andrés
  • Ana Ramírez-Boscá
  • Beatriz Ruzafa-Costas
  • Eva Núñez-Delegido
  • Miguel A. Carrión-Gutiérrez
  • David Prieto-Merino
  • Francisco Codoñer-Cortés
  • Daniel Ramón-Vidal
  • Salvador Genovés-Martínez
  • Empar Chenoll-Cuadros
  • José M. Pérez-Orquín
  • José A. Picó-Monllor
  • Sara Chumillas-Lidón

DOI:

https://doi.org/10.2340/00015555-3305

Keywords:

psoriasis, dermatology, probiotic, microbiome, microbiota

Abstract

The aim of this 12-week randomized, double-blind, placebo-controlled trial was to determine the efficacy and safety of a probiotic mixture in the reduction of psoriasis severity. Ninety 18?70-year-old adults with plaque psoriasis were randomized into probiotic and placebo groups. At 12-week follow-up, 66.7% of patients in the probiotic group and 41.9% in the placebo group showed a reduction in Psoriasis Area and Severity Index of at least 75% (p?<?0.05). A clinically relevant difference was observed in Physician Global Assessment index: 48.9% in the probiotic group achieved a score of 0 or 1, compared with 30.2% in the placebo group. The results of follow-up 6 months after the end of the study showed a lower risk of relapse after the intake of the probiotic mixture. Analysis of gut microbiota confirmed the efficacy of the probiotic in modulation of the microbiota composition.

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Published

2019-09-12

How to Cite

Navarro-López, V., Martínez-Andrés, A., Ramírez-Boscá, A., Ruzafa-Costas, B., Núñez-Delegido, E., Carrión-Gutiérrez, M. A., … Chumillas-Lidón, S. (2019). Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical Trial. Acta Dermato-Venereologica, 99(12), 1078–1084. https://doi.org/10.2340/00015555-3305

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Section

Articles