Unusual Cutaneous Reaction at Site of Methotrexate Injection in Two Patients with Psoriasis and Psoriatic Arthritis

Authors

  • Birgit Sadoghi
  • Birger Kränke
  • Lorenzo Cerroni
  • Wolfgang Weger Department of Dermatology and Venereology, Medical University of Graz, Auenbruggerplatz 8, AT-8036 Graz, Austria

DOI:

https://doi.org/10.2340/actadv.v101.352

Keywords:

psoriasis, injection site reaction, methotrexate, side effect, adverse reaction

Abstract

Abstract is missing (Short communication)

Downloads

Download data is not yet available.

References

Boehncke WH, Schön MP. Psoriasis. Lancet 2015; 386: 983-994.

https://doi.org/10.1016/S0140-6736(14)61909-7 DOI: https://doi.org/10.1016/S0140-6736(14)61909-7

Nast A, Boehncke WH, Morwitz U, Ockenfels HM, Philipp S, Rosenbach T, et al. S3 guidelines for the treatment of psoriasis vulgaris. Update 2011. Available from: http://www.awmf.org/uploads/tx_szleitlinien/013-001l_S3_Psoriasis_vulgaris_Therapie_01.pdf.

Sbidian E, Chaimani A, Afach S, Doney L, Dressler C, Hua C. Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis. Cochrane Database Syst Rev 2021; 4: CD011535.

https://doi.org/10.1002/14651858.CD011535.pub4 DOI: https://doi.org/10.1002/14651858.CD011535.pub4

Shiver MB, Hall AE, Conner KB, Brown GE, Cheung WL, Wirges ML. Cutaneous erosions: a herald for impending pancytopenia in methotrexate toxicity. Dermatol Online J 2014; 20: 13030.

https://doi.org/10.5070/D3207023133 DOI: https://doi.org/10.5070/D3207023133

Czarnecka-Operacz M, Sadowska-Przytocka A. The possibilities and principles of methotrexate treatment of psoriasis - the updated knowledge. Postepy Dermatol Allergol 2014; 31: 392-400.

https://doi.org/10.5114/pdia.2014.47121 DOI: https://doi.org/10.5114/pdia.2014.47121

Delyon J, Ortonne N, Benayoun E, Moroch J, Wolkenstein P, Sbidian E, et al. O. Low-dose methotrexate induced skin toxicity: keratinocyte dystrophy as a histologic marker. J Am Acad Dermatol 2015; 73: 484-490.

https://doi.org/10.1016/j.jaad.2015.06.015 DOI: https://doi.org/10.1016/j.jaad.2015.06.015

Zeltser R, Valle L, Tanck C, Holyst MM, Ritchlin, Gaspari AA. Clinical, histological, and immunophenotypic characteristics of injection site reactions associated with etanercept: a recombinant tumor necrosis factor alpha receptor: Fc fusion protein Arch Dermatol 2001; 137: 893-899.

Shear NH, Paul C, Blauvelt A Gooderham M, Leonardi C, Reich K, et al. Safety and tolerability of ixekizumab: integrated analysis of injection-site reactions from 11 clinical trials. J Drugs Dermatol 2018; 17: 200-206.

Corominas M, Gastaminza G, Lobera T. Hypersensitivity reactions to biological drugs. J Invest Allergol Clin Immunol 2014; 24: 212-225.

Benucci M, Manfredi M, Demoly P, Campi P. Injection site reactions to TNF alpha blocking agents with positive skin tests. Allergy 2008; 63: 138-139.

https://doi.org/10.1111/j.1398-9995.2007.01536.x DOI: https://doi.org/10.1111/j.1398-9995.2007.01536.x

Nakamizo S, Miyachi Y, Kabashima K. Addition of cyclosporine to adalimimab improved psoriasis and adalimumab. Induced injection site reaction. Indian J Dermatol 2014; 59: 522-523.

https://doi.org/10.4103/0019-5154.139924 DOI: https://doi.org/10.4103/0019-5154.139924

Özkaya E. Fixed drug eruption: state of the art. J Dtsch Dermatol Ges 2008; 6: 181-188.

https://doi.org/10.1111/j.1610-0387.2007.06491.x DOI: https://doi.org/10.1111/j.1610-0387.2007.06491.x

Published

2021-11-16

How to Cite

Sadoghi, B., Kränke, B., Cerroni, L., & Weger, W. (2021). Unusual Cutaneous Reaction at Site of Methotrexate Injection in Two Patients with Psoriasis and Psoriatic Arthritis. Acta Dermato-Venereologica, 101(11), adv00593. https://doi.org/10.2340/actadv.v101.352

Issue

Section

Short Communication

Categories