Real-World Treatment Patterns and Treatment Benefits among Adult Patients with Atopic Dermatitis: Results from the Atopic Dermatitis Patient Satisfaction and Unmet Need Survey
DOI:
https://doi.org/10.2340/actadv.v102.3932Keywords:
atopic dermatitis, patient satisfaction, clinical practice patterns, disease management, patient outcome assessmentAbstract
Atopic dermatitis is a chronic inflammatory skin disorder associated with a heterogeneous presentation and considerable disease burden. Exploring atopic dermatitis treatment patterns and patient benefits could improve disease management and patients’ quality of life. This study aimed to describe current and previous atopic dermatitis treatment patterns and patient benefits from those treatments to inform disease management. Data were collected in 10 countries. Adults (n = 1,988) with confirmed moderate-to-severe atopic dermatitis completed a web-based cross-sectional survey. Most patients (86.6%) had body surface area involvement <10%, and therapies used were topical (69.7%), systemic (28.1%), and biologics (2.3%). Most flares were managed by topical monotherapies (73.4%), even in patients with body surface area involvement ≥10%. Treatment expectations were met only partially, or not at all, in 75% of patients. Those with body surface area involvement ≥10% reported lower treatment satisfaction. Overall, this study highlights the unmet medical needs in atopic dermatitis management.
Downloads
References
Augustin M, Langenbruch A, Blome C, Gutknecht M, Werfel T, Ständer S, et al. Characterizing treatment-related patient needs in atopic eczema: insights for personalized goal orientation. J Eur Acad Dermatol Venereol 2020; 34: 142-152.
https://doi.org/10.1111/jdv.15919 DOI: https://doi.org/10.1111/jdv.15919
Calzavara Pinton P, Cristaudo A, Foti C, Canonica GW, Balato N, Costanzo A, et al. Diagnosis and management of moderate to severe adult atopic dermatitis: a Consensus by the Italian Society of Dermatology and Venereology (SIDeMaST), the Italian Association of Hospital Dermatologists (ADOI), the Italian Society of Allergy, Asthma and Clinical Immunology (SIAAIC), and the Italian Society of Allergological, Environmental and Occupational Dermatology (SIDAPA). G Ital Dermatol Venereol 2018; 153: 133-145.
https://doi.org/10.23736/S0392-0488.17.05892-8 DOI: https://doi.org/10.23736/S0392-0488.17.05892-8
Wollenberg A, Barbarot S, Bieber T, Christen-Zaech S, Deleuran M, Fink-Wagner A, et al. Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I. J Eur Acad Dermatol Venereol 2018; 32: 657-682.
https://doi.org/10.1111/jdv.14891 DOI: https://doi.org/10.1111/jdv.14891
Wollenberg A, Christen-Zäch S, Taieb A, Paul C, Thyssen JP, Bruin-Weller M, et al. ETFAD/EADV Eczema task force 2020 position paper on diagnosis and treatment of atopic dermatitis in adults and children. J Eur Acad of Dermatol and Venereol 2020; 34: 2717-2744.
https://doi.org/10.1111/jdv.16892 DOI: https://doi.org/10.1111/jdv.16892
Schmitt J, Csötönyi F, Bauer A, Meurer M. Determinants of treatment goals and satisfaction of patients with atopic eczema. J Dtsch Dermatol Ges 2008; 6: 458-465.
https://doi.org/10.1111/j.1610-0387.2007.06609.x DOI: https://doi.org/10.1111/j.1610-0387.2007.06609.x
Boguniewicz M, Alexis AF, Beck LA, Block J, Eichenfield LF, Fonacier L, et al. Expert perspectives on management of moderate-to-severe atopic dermatitis: a multidisciplinary consensus addressing current and emerging therapies. J Allergy Clin Immunol Pract 2017; 5: 1519-1531.
https://doi.org/10.1016/j.jaip.2017.08.005 DOI: https://doi.org/10.1016/j.jaip.2017.08.005
Simpson EL, Bruin-Weller M, Flohr C, Ardern-Jones MR, Barbarot S, Deleuran M, et al. When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council. J Am Acad Dermatol 2017; 77: 623-633.
https://doi.org/10.1016/j.jaad.2017.06.042 DOI: https://doi.org/10.1016/j.jaad.2017.06.042
Augustin M, Radtke MA, Zschocke I, Blome C, Behechtnejad J, Schäfer I, et al. The patient benefit index: a novel approach in patient-defined outcomes measurement for skin diseases. Arch Dermatol Res 2009; 301: 561-571.
https://doi.org/10.1007/s00403-009-0928-8 DOI: https://doi.org/10.1007/s00403-009-0928-8
Dhadwal G, Albrecht L, Gniadecki R, Poulin Y, Yeung J, Hong C-H, et al. Approach to the assessment and management of adult patients with atopic dermatitis: a consensus document. Section IV: treatment options for the management of atopic dermatitis. J Cutan Med Surg 2018; 22: 21S-9S.
https://doi.org/10.1177/1203475418805721 DOI: https://doi.org/10.1177/1203475418805721
National Institute for Health and Care Excellence (NICE). Frequency of application of topical corticosteroids for atopic eczema. Technology appraisal guidance 2004. London: NICE.
Rubel D, Thirumoorthy T, Soebaryo RW, Weng SCK, Gabriel TM, Villafuerte LL, et al. Consensus guidelines for the management of atopic dermatitis: An Asia-Pacific perspective. J Dermatol 2013; 40: 160-171.
https://doi.org/10.1111/1346-8138.12065 DOI: https://doi.org/10.1111/1346-8138.12065
Fougerousse A-C, Jacobzone C, Mery-Bossard L, Reguiai Z, Droitcourt C, Taieb C, et al. Use of systemic medications for treating adult atopic dermatitis in France: results of a practice survey. Clin Cosmet Investig Dermatol 2021; 14: 179-183.
https://doi.org/10.2147/CCID.S300402 DOI: https://doi.org/10.2147/CCID.S300402
Johnson BB, Franco AI, Beck LA, Prezzano JC. Treatment resistant atopic dermatitis: challenges and solutions. Clin Cosmet Investig Dermatol 2019; 12: 181-192.
https://doi.org/10.2147/CCID.S163814 DOI: https://doi.org/10.2147/CCID.S163814
Bieber T. Atopic dermatitis: an expanding therapeutic pipeline for a complex disease. Nat Rev Drug Discov 2022; 21: 21-40.
https://doi.org/10.1038/s41573-021-00266-6 DOI: https://doi.org/10.1038/s41573-021-00266-6
Published
How to Cite
License
Copyright (c) 2022 Matthias Augustin, Antonio Costanzo, Andrew Pink, Julien Seneschal, Christopher Schuster, Can Mert, Mariana Guerreiro, Nicole Tietz, Susanne Grond, Marjolein de Bruin-Weller
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.
Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.