Does Molluscum Contagiosum Need to be Managed Differently in Atopic Children?
DOI:
https://doi.org/10.2340/actadv.v104.39983Keywords:
Atopic Dermatitis, Molluscum Contagiosum, Pediatric DermatologyAbstract
The association between molluscum contagiosum and concomitant atopic dermatitis and its impact on clinical features and treatment outcomes remains unclear. This retrospective study, conducted in the paediatric dermatology clinic of a tertiary medical centre, aimed to compare molluscum patients with and without atopic dermatitis. A total of 615 children with molluscum were included, 13.17% of whom had atopic dermatitis. While the latter group exhibited higher lesion count and itchiness (p=0.026 and p=0.044, respectively), no significant differences were observed in average lesion diameter, ulceration, purulence, and erythema (p=0.239, p=0.730, p=0.682, and p=0.296, respectively). Both groups showed comparable responses to molluscum-specific and supportive treatments, with no distinct difference in outcomes or recurrence of visits. It was concluded that atopic dermatitis does not exacerbate molluscum morbidity, inflammation markers, treatment outcomes or recurrence rates.
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Hebert AA, Bhatia N, Del Rosso JQ. Molluscum contagiosum: epidemiology, considerations, treatment options, and therapeutic gaps. J Clin Aesthetic Dermatol 2023; 16: S4-11.
Shisler JL. Immune evasion strategies of molluscum contagiosum virus. Adv Virus Res 2015; 92: 201-252.
https://doi.org/10.1016/bs.aivir.2014.11.004 DOI: https://doi.org/10.1016/bs.aivir.2014.11.004
Meza-Romero R, Navarrete-Dechent C, Downey C. Molluscum contagiosum: an update and review of new perspectives in etiology, diagnosis, and treatment. Clin Cosmet Investig Dermatol 2019; 12: 373-381.
https://doi.org/10.2147/CCID.S187224 DOI: https://doi.org/10.2147/CCID.S187224
Silverberg NB. Pediatric molluscum: an update. Cutis 2019; 104: 301-305; E1; E2.
Seize MB, Ianhez M, Cestari Sda C. A study of the correlation between molluscum contagiosum and atopic dermatitis in children. An Bras Dermatol 2011; 86: 663-668.
https://doi.org/10.1590/S0365-05962011000400006 DOI: https://doi.org/10.1590/S0365-05962011000400006
Olsen JR, Piguet V, Gallacher J, Francis NA. Molluscum contagiosum and associations with atopic eczema in children: a retrospective longitudinal study in primary care. Br J Gen Pract 2016; 66: e53-58.
https://doi.org/10.3399/bjgp15X688093 DOI: https://doi.org/10.3399/bjgp15X688093
Dohil MA, Lin P, Lee J, Lucky AW, Paller AS, Eichenfield LF. The epidemiology of molluscum contagiosum in children. J Am Acad Dermatol 2006; 54: 47-54.
https://doi.org/10.1016/j.jaad.2005.08.035 DOI: https://doi.org/10.1016/j.jaad.2005.08.035
Zhang LQ, Zhang YT, Tan C. Molluscum contagiosum with halo dermatitis. J Allergy Clin Immunol Pract 2021; 9: 3805-3806.
https://doi.org/10.1016/j.jaip.2021.06.038 DOI: https://doi.org/10.1016/j.jaip.2021.06.038
Leshem YA, Sugerman PB, Weil C, Chodick G, Liang H, Wang H, et al. Cutaneous comorbidities associated with atopic dermatitis in Israel: a retrospective real-world data analysis. Dermat Contact Atopic Occup Drug 2022; 33: S61-68.
https://doi.org/10.1097/DER.0000000000000841 DOI: https://doi.org/10.1097/DER.0000000000000841
Silverberg NB. Molluscum contagiosum virus infection can trigger atopic dermatitis disease onset or flare. Cutis 2018; 102: 191-194.
Hayashida S, Furusho N, Uchi H, Miyazaki S, Eiraku K, Gondo C, et al. Are lifetime prevalence of impetigo, molluscum and herpes infection really increased in children having atopic dermatitis? J Dermatol Sci 2010; 60: 173-178.
https://doi.org/10.1016/j.jdermsci.2010.09.003 DOI: https://doi.org/10.1016/j.jdermsci.2010.09.003
Osio A, Deslandes E, Saada V, Morel P, Guibal F. Clinical characteristics of molluscum contagiosum in children in a private dermatology practice in the greater Paris area, France: a prospective study in 661 patients. Dermatol Basel Switz 2011; 222: 314-320.
https://doi.org/10.1159/000327888 DOI: https://doi.org/10.1159/000327888
McCollum AM, Holman RC, Hughes CM, Mehal JM, Folkema AM, Redd JT, et al. Molluscum contagiosum in a pediatric American Indian population: incidence and risk factors. PloS One 2014; 9: e103419.
https://doi.org/10.1371/journal.pone.0103419 DOI: https://doi.org/10.1371/journal.pone.0103419
Aalto-Korte K. Improvement of skin barrier function during treatment of atopic dermatitis. J Am Acad Dermatol 1995; 33: 969-972.
https://doi.org/10.1016/0190-9622(95)90288-0 DOI: https://doi.org/10.1016/0190-9622(95)90288-0
Oganesyan A, Sivesind TE, Dellavalle R. From the Cochrane Library: interventions for cutaneous molluscum contagiosum. JMIR Dermatol 2023; 6: e41514.
https://doi.org/10.2196/41514 DOI: https://doi.org/10.2196/41514
van der Wouden JC, van der Sande R, Kruithof EJ, Sollie A, van Suijlekom-Smit LW, Koning S. Interventions for cutaneous molluscum contagiosum. Cochrane Database Syst Rev 2017; 2017: CD004767.
https://doi.org/10.1002/14651858.CD004767.pub4 DOI: https://doi.org/10.1002/14651858.CD004767.pub4
Ong PY, Leung DYM. Bacterial and viral infections in atopic dermatitis: a comprehensive review. Clin Rev Allergy Immunol 2016; 51: 329-337.
https://doi.org/10.1007/s12016-016-8548-5 DOI: https://doi.org/10.1007/s12016-016-8548-5
Pols DHJ, Nielen MMJ, Bohnen AM, Korevaar JC, Bindels PJE. Atopic children and use of prescribed medication: a comprehensive study in general practice. PLoS ONE 2017; 12: e0182664.
https://doi.org/10.1371/journal.pone.0182664 DOI: https://doi.org/10.1371/journal.pone.0182664
Center for Drug Evaluation and Research. FDA approves first treatment for molluscum contagiosum. FDA. 2023 Jul 24 [cited 2024 Jan 17]; Available from: https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-first-treatment-molluscum-contagiosum.
Dermatology Times. 2024 [cited 2024 Jan 17]. FDA approves berdazimer gel, 10.3% for the treatment of molluscum contagiosum. Available from: https://www.dermatologytimes.com/view/fda-approves-berdazimer-gel-10-3-for-the-treatment-of-molluscum-contagiosum.
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