Improvement of Skin Lesions in an Adult with CHILD Syndrome Treated with 2% Ketoconazole Cream

Authors

  • Michiya Omi Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • Kana Tanahashi Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • Takuya Takeichi Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • Masashi Akiyama Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan

DOI:

https://doi.org/10.2340/actadv.v104.41929

Keywords:

congenital hemidysplasia with ichthyosiform naevus and limb defects, cholesterol, CYP51, ichthyosis, squalene

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References

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https://doi.org/10.1038/jid.2011.189 DOI: https://doi.org/10.1038/jid.2011.189

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https://doi.org/10.1038/gim.2015.30 DOI: https://doi.org/10.1038/gim.2015.30

Liu T, Qian G, Wang XX, Zhang YG. CHILD syndrome: effective treatment of ichthyosiform naevus with oral and topical ketoconazole. Acta Derm Venereol 2015; 95: 91-92.

https://doi.org/10.2340/00015555-1859 DOI: https://doi.org/10.2340/00015555-1859

Maceda EBG, Kratz LE, Ramos VME, Abacan MAR. Novel NSDHL gene variant for congenital hemidysplasia with ichthyosiform erythroderma and limb defects (CHILD) syndrome. BMJ Case Rep 2020; 13: e236859.

https://doi.org/10.1136/bcr-2020-236859 DOI: https://doi.org/10.1136/bcr-2020-236859

Huang ZR, Lin YK, Fang JY. Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology. Molecules 2009; 14: 540-554.

https://doi.org/10.3390/molecules14010540 DOI: https://doi.org/10.3390/molecules14010540

Kallis P, Bisbee E, Garganta C, Schoch JJ. Rapid improvement of skin lesions in CHILD syndrome with topical 5% simvastatin ointment. Pediatr Dermatol 2022; 39: 151-152.

https://doi.org/10.1111/pde.14865 DOI: https://doi.org/10.1111/pde.14865

Bajawi SM, Jafarri SA, Buraik MA, Al Attas KM, Hannani HY. Pathogenesis-based therapy: cutaneous abnormalities of CHILD syndrome successfully treated with topical simvastatin monotherapy. JAAD Case Rep 2018; 4: 232-234.

https://doi.org/10.1016/j.jdcr.2017.11.019 DOI: https://doi.org/10.1016/j.jdcr.2017.11.019

Published

2024-11-20

How to Cite

Omi, M., Tanahashi, K., Takeichi, T., & Akiyama, M. (2024). Improvement of Skin Lesions in an Adult with CHILD Syndrome Treated with 2% Ketoconazole Cream. Acta Dermato-Venereologica, 104, adv41929. https://doi.org/10.2340/actadv.v104.41929