Improvement of Skin Lesions in an Adult with CHILD Syndrome Treated with 2% Ketoconazole Cream
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https://doi.org/10.2340/actadv.v104.41929Keywords:
congenital hemidysplasia with ichthyosiform naevus and limb defects, cholesterol, CYP51, ichthyosis, squaleneDownloads
References
Paller AS, van Steensel MA, Rodriguez-Martín M, Jennifer S, Candrice H, Debra C, et al. Pathogenesis-based therapy reverses cutaneous abnormalities in an inherited disorder of distal cholesterol metabolism. J Invest Dermatol 2011; 131: 2242-2248.
https://doi.org/10.1038/jid.2011.189 DOI: https://doi.org/10.1038/jid.2011.189
Richards S, Aziz N, Bale S, Bick D, Das S, Gastier-Foster J, et al. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med 2015; 17: 405-424.
https://doi.org/10.1038/gim.2015.30 DOI: https://doi.org/10.1038/gim.2015.30
Liu T, Qian G, Wang XX, Zhang YG. CHILD syndrome: effective treatment of ichthyosiform naevus with oral and topical ketoconazole. Acta Derm Venereol 2015; 95: 91-92.
https://doi.org/10.2340/00015555-1859 DOI: https://doi.org/10.2340/00015555-1859
Maceda EBG, Kratz LE, Ramos VME, Abacan MAR. Novel NSDHL gene variant for congenital hemidysplasia with ichthyosiform erythroderma and limb defects (CHILD) syndrome. BMJ Case Rep 2020; 13: e236859.
https://doi.org/10.1136/bcr-2020-236859 DOI: https://doi.org/10.1136/bcr-2020-236859
Huang ZR, Lin YK, Fang JY. Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology. Molecules 2009; 14: 540-554.
https://doi.org/10.3390/molecules14010540 DOI: https://doi.org/10.3390/molecules14010540
Kallis P, Bisbee E, Garganta C, Schoch JJ. Rapid improvement of skin lesions in CHILD syndrome with topical 5% simvastatin ointment. Pediatr Dermatol 2022; 39: 151-152.
https://doi.org/10.1111/pde.14865 DOI: https://doi.org/10.1111/pde.14865
Bajawi SM, Jafarri SA, Buraik MA, Al Attas KM, Hannani HY. Pathogenesis-based therapy: cutaneous abnormalities of CHILD syndrome successfully treated with topical simvastatin monotherapy. JAAD Case Rep 2018; 4: 232-234.
https://doi.org/10.1016/j.jdcr.2017.11.019 DOI: https://doi.org/10.1016/j.jdcr.2017.11.019
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Copyright (c) 2024 Omi Michiya, Kana Tanahasi, Takuya Takeichi, Masashi Akiyama

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