Frequency of TNFalpha, IL17RA, and Act1 Genetic Polymorphisms in a Population with Psoriasis Compared with Healthy Individuals: Results in a Multiracial Population in Rio de Janeiro, Brazil
DOI:
https://doi.org/10.2340/actadv.v105.42017Keywords:
TNFA, IL17RA, TRAF3, SNP, BRAZIL, PSORIASISDownloads
References
Christophers E. Psoriasis--epidemiology and clinical spectrum. Clin Exp Dermatol 2001; 26: 314-320.
https://doi.org/10.1046/j.1365-2230.2001.00832.x DOI: https://doi.org/10.1046/j.1365-2230.2001.00832.x
Romiti R, Amone M, Menter A, Miot HA. Prevalence of psoriasis in Brazil - a geographical survey. Int J Dermatol 2017; 56: e167-e168.
https://doi.org/10.1111/ijd.13604 DOI: https://doi.org/10.1111/ijd.13604
Boehncke WH, Schon MP. Psoriasis. Lancet 2015; 386: 983-994.
https://doi.org/10.1016/S0140-6736(14)61909-7 DOI: https://doi.org/10.1016/S0140-6736(14)61909-7
Mateu-Arrom L, Puig L. Genetic and epigenetic mechanisms of psoriasis. Genes (Basel) 2023; 14: 1619.
https://doi.org/10.3390/genes14081619 DOI: https://doi.org/10.3390/genes14081619
Lomholt G. Prevalence of skin diseases in a population; a census study from the Faroe Islands. Dan Med Bull 1964; 11: 1-7.
Finlay AY. Current severe psoriasis and the rule of tens. Br J Dermatol 2005; 152: 861-867.
https://doi.org/10.1111/j.1365-2133.2005.06502.x DOI: https://doi.org/10.1111/j.1365-2133.2005.06502.x
Dand N, Mahil SK, Capon F, Smith CH, Simpson MA, Barker JN. Psoriasis and genetics. Acta Derm Venereol 2020; 100: adv00030.
https://doi.org/10.2340/00015555-3384 DOI: https://doi.org/10.2340/00015555-3384
Douroudis K, Ramessur R, Barbosa IA, Baudry D, Duckworth M, Angit C, et al. Differences in clinical features and comorbid burden between HLA-C *06:02 carrier groups in >9,000 people with psoriasis. J Invest Dermatol 2022; 142: 1617-1628 e1610.
https://doi.org/10.26226/morressier.61081ff8bc981037240fe3af DOI: https://doi.org/10.26226/morressier.61081ff8bc981037240fe3af
Akcılar R, Dizen Namdar N, Yükcü F, Arslan Utku S. TNF-α gene -238G>A polymorphism is associated with psoriasis patients. J Cosmet Dermatol 2022; 21: 2662-2667.
https://doi.org/10.1111/jocd.14940 DOI: https://doi.org/10.1111/jocd.14940
Li C, Wang G, Gao Y, Liu L, Gao T. TNF-alpha gene promoter -238G>A and -308G>A polymorphisms alter risk of psoriasis vulgaris: a meta-analysis. J Invest Dermatol 2007; 127: 1886-1892.
https://doi.org/10.1038/sj.jid.5700822 DOI: https://doi.org/10.1038/sj.jid.5700822
Magalhaes RF, Biral AC, Pancoto JA, Donadi EA, Mendes CT, Jr., Magna LA, et al. Human leukocyte antigen (HLA) and single nucleotide polymorphisms (SNPs) tumor necrosis factor (TNF)-alpha -238 and -308 as genetic markers of susceptibility to psoriasis and severity of the disease in a long-term follow-up Brazilian study. Int J Dermatol 2010; 49: 1133-1140.
https://doi.org/10.1111/j.1365-4632.2010.04465.x DOI: https://doi.org/10.1111/j.1365-4632.2010.04465.x
Batalla A, Coto E, Gonzalez-Lara L, Gonzalez-Fernandez D, Gomez J, Aranguren TF, et al. Association between single nucleotide polymorphisms IL17RA rs4819554 and IL17E rs79877597 and Psoriasis in a Spanish cohort. J Dermatol Sci 2015; 80: 111-115.
https://doi.org/10.1016/j.jdermsci.2015.06.011 DOI: https://doi.org/10.1016/j.jdermsci.2015.06.011
Zhang CJ, Wang C, Jiang M, Gu C, Xiao J, Chen X, et al. Act1 is a negative regulator in T and B cells via direct inhibition of STAT3. Nat Commun 2018; 9: 2745.
https://doi.org/10.1038/s41467-018-04974-3 DOI: https://doi.org/10.1038/s41467-018-04974-3
Malinowski D, Białecka M, Bojko P, Kiszkielis A, Droździk M, Kurzawski M. Analysis of selected genetic variants in psoriasis susceptibility and response to treatment. Postepy Dermatol Alergol 2022; 39: 934-939.
https://doi.org/10.5114/ada.2022.120885 DOI: https://doi.org/10.5114/ada.2022.120885
Liu M, Shi H, Yan J, Zhang Y, Ma Y, Le K, et al. Gene polymorphism-related differences in the outcomes of abiraterone for prostate cancer: a systematic overview. Am J Cancer Res 2021; 11: 1873-1894.
Additional Files
Published
How to Cite
License
Copyright (c) 2025 Ana Luisa Sampaio, Bruna Romana-Souza, Haizza Cristina Cabral de Almeida Monteiro, Camila Oliveira da Silva, Luna Azulay-Abulafia

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.
Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.