Papuloerythroderma of Ofuji Associated with Elevated Varicella-zoster Virus Complement-fixing Antibody Titers Following BNT162b2 mRNA COVID-19 Vaccination
DOI:
https://doi.org/10.2340/actadv.v105.42546Keywords:
papuloerythroderma of Ofuji, varicella-zoster virus, complement-fixing antibody titer, Pfizer–BioNTech COVID-19 (BNT162b2) vaccine, COVID-19, herpes zoster, cutaneous adverse reactionDownloads
References
Ofuji S, Furukawa F, Miyachi Y, Ohno S. Papuloerythroderma. Dermatologica 1984; 169: 125–130.
https://doi.org/10.1159/000249586 DOI: https://doi.org/10.1159/000249586
Torchia D, Miteva M, Hu S, Cohen C, Romanelli P. Papuloerythroderma 2009: two new cases and systematic review of the worldwide literature 25 years after its identification by Ofuji et al. Dermatology 2010; 220: 311–320.
https://doi.org/10.1159/000301915 DOI: https://doi.org/10.1159/000301915
Polack FP, Thomas SJ, Kitchin N, et al. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N Engl J Med 2020; 383: 2603–2615.
https://doi.org/10.1056/NEJMoa2034577 DOI: https://doi.org/10.1056/NEJMoa2034577
McMahon DE, Amerson E, Rosenbach M, et al. Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: a registry-based study of 414 cases. J Am Acad Dermatol 2021; 85: 46–55.
https://doi.org/10.1016/j.jaad.2021.03.092 DOI: https://doi.org/10.1016/j.jaad.2021.03.092
Sun Q, Fathy R, McMahon DE, Freeman EE. COVID-19 vaccines and the skin: the landscape of cutaneous vaccine reactions worldwide. Dermatol Clin 2021; 39: 653–673.
https://doi.org/10.1016/j.det.2021.05.016 DOI: https://doi.org/10.1016/j.det.2021.05.016
Català A, Muñoz-Santos C, Galván-Casas C, et al. Cutaneous reactions after SARS-CoV-2 vaccination: a cross-sectional Spanish nationwide study of 405 cases. Br J Dermatol 2022; 186: 142–152.
https://doi.org/10.1111/bjd.20639 DOI: https://doi.org/10.1111/bjd.20639
Qaderi K, Golezar MH, Mardani A, Mallah MA, Moradi B, Kavoussi H, et al. Cutaneous adverse reactions of COVID-19 vaccines: a systematic review. Dermatol Ther 2022; 35: e15391.
https://doi.org/10.1111/dth.15391 DOI: https://doi.org/10.1111/dth.15391
Avallone G, Quaglino P, Cavallo F, et al. SARS-CoV-2 vaccine-related cutaneous manifestations: a systematic review. Int J Dermatol 2022; 61: 1187–1204.
https://doi.org/10.1111/ijd.16063 DOI: https://doi.org/10.1111/ijd.16063
Cebeci Kahraman F, Savas Erdoğan S, Aktaş ND, et al. Cutaneous reactions after COVID-19 vaccination in Turkey: a multicenter study. J Cosmet Dermatol 2022; 21: 3692–3703.
https://doi.org/10.1111/jocd.15209 DOI: https://doi.org/10.1111/jocd.15209
Oka M, Fujii Y, Murakami S. Late-onset maculopapular eruptions associated with elevated varicella-zoster virus complement-fixing antibody titers following BNT162b2 mRNA COVID-19 vaccination in older adult Japanese patients: a cross-sectional study. Dermatol Ther 2024; 2777924.
https://doi.org/10.1155/2024/2777924 DOI: https://doi.org/10.1155/2024/2777924
Miyachi M, Ihara H, Imafuku S. Incidence of serum antibody titers against varicella zoster virus in Japanese patients with herpes zoster. J Dermatol 2017; 44: 656–659.
https://doi.org/10.1111/1346-8138.13733 DOI: https://doi.org/10.1111/1346-8138.13733
Martinez-Reviejo R, Tejada S, Adebanjo GAR, et al. Varicella-Zoster virus reactivation following severe acute respiratory syndrome coronavirus 2 vaccination or infection: new insights. Eur J Intern Med 2022; 104: 73–79.
https://doi.org/10.1016/j.ejim.2022.07.022 DOI: https://doi.org/10.1016/j.ejim.2022.07.022
Diez-Domingo J, Parikh R, Bhavsar AB, Cisneros E, McCormick N, Lecrenier N. Can COVID-19 increase the risk of herpes zoster? A narrative review. Dermatol Ther 2021; 11: 1119–1126.
https://doi.org/10.1007/s13555-021-00549-1 DOI: https://doi.org/10.1007/s13555-021-00549-1
Préta LH, Contejean A, Salvo F, Treluyer JM, Charlier C, Chouchana L. Association study between herpes zoster reporting and mRNA COVID-19 vaccines (BNT162b2 and mRNA-1273). Br J Clin Pharmacol 2022; 88: 3529–3534.
https://doi.org/10.1111/bcp.15280 DOI: https://doi.org/10.1111/bcp.15280
Hertel M, Heiland M, Nahles S, et al. Real-world evidence from over one million COVID-19 vaccinations is consistent with reactivation of the varicella-zoster virus. J Eur Acad Dermatol Venereol 2022; 36: 1342–1348.
https://doi.org/10.1111/jdv.18184 DOI: https://doi.org/10.1111/jdv.18184
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