The Altered Vascular Endothelial Control of Facial Cutaneous Blood Flow in Rosacea
DOI:
https://doi.org/10.2340/actadv.v105.42800Keywords:
vasodilation, erythematotelangectatic rosacea, sympathetic nervous system, facial flushing, heatDownloads
References
Gether L, Overgaard LK, Egeberg A, Thyssen JP. Incidence and prevalence of rosacea: a systematic review and meta-analysis. Br J Dermatol 2018; 179: 282–289.
https://doi.org/10.1111/bjd.16481 DOI: https://doi.org/10.1111/bjd.16481
van Zuuren EJ, Arents BWM, van der Linden MMD, Vermeulen S, Fedorowicz Z, Tan J. Rosacea: new concepts in classification and treatment. Am J Clin Dermatol 2021; 22: 457–465.
https://doi.org/10.1007/s40257-021-00595-7 DOI: https://doi.org/10.1007/s40257-021-00595-7
Gray B, Metzler-Wilson K, Dawes KW, Wilson TE. A neural link to understanding rosacea: focusing on flushing triggers. J AmOsteop College oDermatol 2015; 33: 11–16.
Gallo RL, Granstein RD, Kang S, Mannis M, Steinhoff M, Tan J, et al. Standard classification and pathophysiology of rosacea: the 2017 update by the National Rosacea Society Expert Committee. J Am Acad Dermatol 2018; 78: 148–155.
https://doi.org/10.1016/j.jaad.2017.08.037 DOI: https://doi.org/10.1016/j.jaad.2017.08.037
Metzler-Wilson K, Toma K, Sammons DL, Mann S, Jurovcik AJ, Demidova O, et al. Augmented supraorbital skin sympathetic nerve activity responses to symptom trigger events in rosacea patients. J Neurophysiol 2015; 114: 1530–1537.
https://doi.org/10.1152/jn.00458.2015 DOI: https://doi.org/10.1152/jn.00458.2015
Elam M, Sverrisdottir YB, Rundqvist B, McKenzie D, Wallin BG, Macefield VG. Pathological sympathoexcitation: how is it achieved? Acta Physiol Scand 2003; 177: 405–411.
https://doi.org/10.1046/j.1365-201X.2003.01080.x DOI: https://doi.org/10.1046/j.1365-201X.2003.01080.x
Low DA, Jones H, Cable NT, Alexander LM, Kenney WL. Historical reviews of the assessment of human cardiovascular function: interrogation and understanding of the control of skin blood flow. Eur J Appl Physiol 2020; 120: 1–16.
https://doi.org/10.1007/s00421-019-04246-y DOI: https://doi.org/10.1007/s00421-019-04246-y
Sasano H, Hayano J, Tsuda T, Katsuya H. Effects of sympathetic nerve blockades on low-frequency oscillations of human earlobe skin blood flow. J Auton Nerv Syst 1999; 77: 60–67.
https://doi.org/10.1016/S0165-1838(99)00029-6 DOI: https://doi.org/10.1016/S0165-1838(99)00029-6
Soderstrom T, Stefanovska A, Veber M, Svensson H. Involvement of sympathetic nerve activity in skin blood flow oscillations in humans. Am J Physiol Heart Circ Physiol 2003; 284: H1638–1646.
https://doi.org/10.1152/ajpheart.00826.2000 DOI: https://doi.org/10.1152/ajpheart.00826.2000
Wilson TE, Zhang R, Levine BD, Crandall CG. Dynamic autoregulation of cutaneous circulation: differential control in glabrous versus nonglabrous skin. Am J Physiol Heart Circ Physiol 2005; 289: H385–391.
https://doi.org/10.1152/ajpheart.00622.2004 DOI: https://doi.org/10.1152/ajpheart.00622.2004
Benedicic M, Bernjak A, Stefanovska A, Bosnjak R. Continuous wavelet transform of laser-Doppler signals from facial microcirculation reveals vasomotion asymmetry. Microvasc Res 2007; 74: 45–50.
https://doi.org/10.1016/j.mvr.2007.02.007 DOI: https://doi.org/10.1016/j.mvr.2007.02.007
Guzman-Sanchez DA, Ishiuji Y, Patel T, Fountain J, Chan YH, Yosipovitch G. Enhanced skin blood flow and sensitivity to noxious heat stimuli in papulopustular rosacea. J Am Acad Dermatol 2007; 57: 800–805.
https://doi.org/10.1016/j.jaad.2007.06.009 DOI: https://doi.org/10.1016/j.jaad.2007.06.009
Yamasaki K, Kanada K, Macleod DT, Borkowski AW, Morizane S, Nakatsuji T, et al. TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes. J Invest Dermatol 2011; 131: 688–697.
https://doi.org/10.1038/jid.2010.351 DOI: https://doi.org/10.1038/jid.2010.351
Moura AKA, Guedes F, Rivitti-Machado MC, Sotto MN. Innate immunity in rosacea. Langerhans cells, plasmacytoid dentritic cells, Toll-like receptors and inducible oxide nitric synthase (iNOS) expression in skin specimens: case-control study. Arch Dermatol Res 2018; 310: 139–146.
https://doi.org/10.1007/s00403-018-1806-z DOI: https://doi.org/10.1007/s00403-018-1806-z
Miller JT, Turner CG, Otis JS, Sebeh Y, Hayat MJ, Quyyumi AA, et al. Inhibition of iNOS augments cutaneous endothelial NO-dependent vasodilation in prehypertensive non-Hispanic Whites and in non-Hispanic Blacks. Am J Physiol Heart Circ Physiol 2021; 320: H190–H199.
https://doi.org/10.1152/ajpheart.00644.2020 DOI: https://doi.org/10.1152/ajpheart.00644.2020
Published
How to Cite
License
Copyright (c) 2025 C. Ilinca Ungureanu, Megan J. Kube, Thad E. Wilson, Kristen Metzler-Wilson

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.
Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.