Paxbp1 is Indispensable for the Maintenance of Hair Follicle Homeostasis

Cong Huang; Wenting Li; Shizheng Zhao; Wei Zhang; Bo Yu

doi:10.2340/actadv.v105.43648

Authors

Cong Huang Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China; Shenzhen Key Laboratory for Translational Medicine of Dermatology, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong, China
Wenting Li The Digestive and Reproductive System Cancers Precise Prevention Engineering Research Center of Jiangsu Province, Institute of Medicinal Biotechnology, Jiangsu College of Nursing, Huai’ an, Jiangsu, China
Shizheng Zhao Biomedical Research Institute, Shenzhen Peking University-the Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong, China
Wei Zhang Biomedical Research Institute, Shenzhen Peking University-the Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong, China
Bo Yu Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China; Shenzhen Key Laboratory for Translational Medicine of Dermatology, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong, China

DOI:

https://doi.org/10.2340/actadv.v105.43648

Keywords:

Paxbp1, hair follicle, RNA-Seq

Downloads

Download data is not yet available.

References

Diao Y, Guo X, Li Y, Sun K, Lu L, Jiang L, et al. Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism. Cell Stem Cell 2012; 11: 231–241.

https://doi.org/10.1016/j.stem.2012.05.022 DOI: https://doi.org/10.1016/j.stem.2012.05.022

Alharby E, Albalawi AM, Nasir A, Alhijji SA, Mahmood A, Ramzan K, et al. A homozygous potentially pathogenic variant in the PAXBP1 gene in a large family with global developmental delay and myopathic hypotonia. Clin Genet 2017; 92: 579–986.

https://doi.org/10.1111/cge.13051 DOI: https://doi.org/10.1111/cge.13051

Zhou S, Han L, Weng M, Zhu H, Heng Y, Wang G, et al. Paxbp1 controls a key checkpoint for cell growth and survival during early activation of quiescent muscle satellite cells. Proc Natl Acad Sci U S A 2021; 118: e2021093118.

https://doi.org/10.1073/pnas.2021093118 DOI: https://doi.org/10.1073/pnas.2021093118

Li W, Yang Y, Liu S, Zhang D, Ren X, Tang M, et al. Paxbp1 is indispensable for the survival of CD4 and CD8 double-positive thymocytes. Front Immunol 2023; 14: 1183367.

https://doi.org/10.3389/fimmu.2023.1183367 DOI: https://doi.org/10.3389/fimmu.2023.1183367

Huang C, Liu S, Li W, Zhao S, Ren X, Zhuo F, et al. Paxbp1 is indispensable for the maintenance of epidermal homeostasis. J Invest Dermatol 2025; 145: 864–875.

https://doi.org/10.1016/j.jid.2024.08.012 DOI: https://doi.org/10.1016/j.jid.2024.08.012

Rishikaysh P, Dev K, Diaz D, Qureshi WM, Filip S, Mokry J. Signaling involved in hair follicle morphogenesis and development. Int J Mol Sci 2014; 15: 1647–1670.

https://doi.org/10.3390/ijms15011647 DOI: https://doi.org/10.3390/ijms15011647

Frech S, Forsthuber A, Korosec A, Lipp K, Kozumov V, Lichtenberger BM. Hedgehog signaling in papillary fibroblasts is essential for hair follicle regeneration during wound healing. J Invest Dermatol 2022; 142: 1737–1748.

https://doi.org/10.1016/j.jid.2021.11.026 DOI: https://doi.org/10.1016/j.jid.2021.11.026

El-Brolosy MA, Stainier DYR. Genetic compensation: a phenomenon in search of mechanisms. PLoS Genet 2017; 13: e1006780.

https://doi.org/10.1371/journal.pgen.1006780 DOI: https://doi.org/10.1371/journal.pgen.1006780