Treatment of Digital Ulcers and Reflux Oesophagitis in a Patient with Systemic Sclerosis: Increased Risk of Hepatotoxicity due to a Potential Drug-drug Interaction Between Bosentan and Vonoprazan


  • Ryoko Kimura Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago 683-8503, Japan
  • Kazunari Sugita
  • Takaaki Sugihara
  • Hajime Isomoto
  • Osamu Yamamoto



systemic scleroderma, bosentan, lansoprazole, vonoprazan fumarate


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How to Cite

Kimura, R., Sugita, K., Sugihara, T., Isomoto, H., & Yamamoto, O. (2021). Treatment of Digital Ulcers and Reflux Oesophagitis in a Patient with Systemic Sclerosis: Increased Risk of Hepatotoxicity due to a Potential Drug-drug Interaction Between Bosentan and Vonoprazan. Acta Dermato-Venereologica, 101(11), adv00600.