Dupilumab Achieves Early Disease Control in Bullous Pemphigoid: A Case Series with TARC-based Biomarker Evaluation

Authors

  • Saori Takamura Department of Dermatology, Saitama Medical Center, Saitama Medical University, Saitama, Japan
  • Tomoo Fukuda Department of Dermatology, Saitama Medical Center, Saitama Medical University, Saitama, Japan

DOI:

https://doi.org/10.2340/actadv.v105.43999

Keywords:

bullous pemphigoid, dupilumab, biologic therapy, IL-4, IL-13, disease activity biomarkers, thymus and activation-regulated chemokine

Downloads

Download data is not yet available.

References

Kridin K. Subepidermal autoimmune bullous diseases: overview, epidemiology, and associations. Immunol Res 2018; 66: 6–17. DOI: https://doi.org/10.1007/s12026-017-8975-2

Simpson EL, Bieber T, Guttman-Yassky E, Beck LA, Blauvelt A, Cork MJ, et al. Two phase 3 trials of dupilumab versus placebo in atopic dermatitis. N Engl J Med 2016; 375: 2335–2348. DOI: https://doi.org/10.1056/NEJMoa1610020

Cao P, Xu W, Zhang L. Rituximab, omalizumab, and dupilumab treatment outcomes in bullous pemphigoid: a systematic review. Front Immunol 2022; 13: 928621. DOI: https://doi.org/10.3389/fimmu.2022.928621

Zhao L, Wang Q, Liang G, Zhou Y, Yiu N, Yang B, et al. Evaluation of dupilumab in patients with bullous pemphigoid. JAMA Dermatol 2023; 159: 953–960. DOI: https://doi.org/10.1001/jamadermatol.2023.2428

Huang D, Zhang Y, Yu Y, Jiang Y, Kong L, Ding Y, et al. Long-term efficacy and safety of dupilumab for severe bullous pemphigoid: a prospective cohort study. Int Immunopharmacol 2023; 125: 111157. DOI: https://doi.org/10.1016/j.intimp.2023.111157

Kakinuma T, Nakamura K, Wakugawa M, Mitsui H, Tada Y, Saeki H, et al. Thymus and activation-regulated chemokine in atopic dermatitis: serum thymus and activation-regulated chemokine level is closely related with disease activity. J Allergy Clin Immunol 2001; 107: 535–541. DOI: https://doi.org/10.1067/mai.2001.113237

Kakinuma T, Wakugawa M, Nakamura K, Hino H, Matsushima K, Tamaki K. High level of thymus and activation-regulated chemokine in blister fluid and sera of patients with bullous pemphigoid. Br J Dermatol 2003; 148: 203–210. DOI: https://doi.org/10.1046/j.1365-2133.2003.05066.x

Suzuki M, Yamaguchi Y, Nakamura K, Kanaoka M, Matsukura S, Takahashi K, et al. Serum thymus and activation-regulated chemokine (TARC/CCL17) may be useful to predict the disease activity in patients with bullous pemphigoid. J Eur Acad Dermatol Venereol 2021; 35: e121–e124. DOI: https://doi.org/10.1111/jdv.16851

Published

2025-07-01

How to Cite

Takamura, S., & Fukuda, T. (2025). Dupilumab Achieves Early Disease Control in Bullous Pemphigoid: A Case Series with TARC-based Biomarker Evaluation. Acta Dermato-Venereologica, 105, adv43999. https://doi.org/10.2340/actadv.v105.43999