Is Spontaneous Regrowth in Alopecia Areata Possible: A Systematic Review and Meta-analysis of Placebo-controlled Studies

Authors

  • Beata Jastrząb-Miśkiewicz University Centre of General Dermatology and Oncodermatology, Wroclaw Medical University, Wroclaw, Poland
  • Jacek C. Szepietowski Division of Dermatology, Venereology and Clinical Immunology, Faculty of Medicine, Wroclaw University of Science and Technology, Wroclaw, Poland; Department of Dermatovenereology, 4th Military Hospital, Wroclaw, Poland
  • David Saceda Corralo Servicio de Dermatología, Hospital Universitario Ramón y Cajal, IRyCIS, Madrid, Spain; Hair Disorders Unit, Grupo Pedro Jaén, Madrid, Spain
  • Piotr K. Krajewski University Centre of General Dermatology and Oncodermatology, Wroclaw Medical University, Wroclaw, Poland

DOI:

https://doi.org/10.2340/actadv.v105.44153

Keywords:

alopeica areata, meta-analysis, hair loss

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References

Sterkens A, Lambert J, Bervoets A. Alopecia areata: a review on diagnosis, immunological etiopathogenesis and treatment options. Clin Exp Med 2021; 21: 215–230. DOI: https://doi.org/10.1007/s10238-020-00673-w

Zhou C, Li X, Wang C, Zhang J. Alopecia areata: an update on etiopathogenesis, diagnosis, and management. Clin Rev

Allergy Immunol 2021; 61: 403–423. DOI: https://doi.org/10.1007/s12016-021-08883-0

Tosti A, Bellavista S, Iorizzo M. Alopecia areata: a long term follow-up study of 191 patients. J Am Acad Dermatol 2006; 55: 438–441. DOI: https://doi.org/10.1016/j.jaad.2006.05.008

Mesinkovska N, Craiglow B, Ball SG, Morrow P, Smith SG, Pierce E, et al. The invisible impact of a visible disease: psychosocial impact of alopecia areata. Dermatol Ther (Heidelb) 2023; 13: 1503–1515. DOI: https://doi.org/10.1007/s13555-023-00941-z

Olsen EA, Hordinsky MK, Price VH, Roberts JL, Shapiro J, Canfield D, et al. Alopecia areata investigational assessment guidelines – Part II. National Alopecia Areata Foundation. J Am Acad Dermatol 2004; 51: 440–447. DOI: https://doi.org/10.1016/j.jaad.2003.09.032

Islam N, Leung PS, Huntley AC, Gershwin ME. The autoimmune basis of alopecia areata: a comprehensive review. Autoimmun Rev 2015; 14: 81–89. DOI: https://doi.org/10.1016/j.autrev.2014.10.014

Lepe K, Syed HA, Zito PM. Alopecia areata. 2024 Feb 8. In: StatPearls [Internet]. Treasure Island, FL: StatPearls Publishin, 2025.

Fernandez-Gonzalez P, Saceda-Corralo D, Pindado-Ortega C, Buendia-Castaño D, Fernández-Guarino M, Vañó-Galván S. Spontaneous hair regrowth in eight patients with severe alopecia areata. Australas J Dermatol 2018; 59: e318–e319. DOI: https://doi.org/10.1111/ajd.12840

Published

2025-10-28

How to Cite

Jastrząb-Miśkiewicz, B., Szepietowski, J. C., Saceda Corralo, D., & Krajewski, P. K. (2025). Is Spontaneous Regrowth in Alopecia Areata Possible: A Systematic Review and Meta-analysis of Placebo-controlled Studies. Acta Dermato-Venereologica, 105, adv44153. https://doi.org/10.2340/actadv.v105.44153

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