Functional Brain Imaging Reveals Reconstitution of the Central Nervous Itch Network Upon Rifampicin Therapy in Hepatobiliary Pruritus
DOI:
https://doi.org/10.2340/actadv.v105.44350Keywords:
pruritus, cholestatic liver diseases, rifampicin, fMRIDownloads
References
Kremer AE, Mettang T, Weisshaar E. Non-dermatological challenges of chronic itch. Acta Derm Venereol 2020; 100: adv00025. DOI: https://doi.org/10.2340/00015555-3345
Kremer AE, van Dijk R, Leckie P, Schaap FG, Kuiper EM, Mettang T, et al. Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions. Hepatology 2012; 56: 1391–1400. DOI: https://doi.org/10.1002/hep.25748
Tandon P, Rowe BH, Vandermeer B, Bain VG. The efficacy and safety of bile acid binding agents, opioid antagonists, or rifampin in the treatment of cholestasis-associated pruritus. Am J Gastroenterol 2007; 102: 1528–1536. DOI: https://doi.org/10.1111/j.1572-0241.2007.01200.x
Najafi P, Carré J-L, Ben Salem D, Brenaut E, Misery L, Dufor O. Central mechanisms of itch: a systematic literature review and meta-analysis. J Neuroradiol 2020; 47: 450–457. DOI: https://doi.org/10.1016/j.neurad.2019.11.005
Cheddad El Aouni M, Ben Salem D, Misery L. Functional MRI of pruritus. J Neuroradiol 2020; 47: 400–401. DOI: https://doi.org/10.1016/j.neurad.2020.09.001
Mosher VAL, Swain MG, Pang JXQ, Kaplan GG, Sharkey KA, MacQueen GM, et al. Primary biliary cholangitis alters functional connections of the brain’s deep gray matter. Clin Transl Gastroenterol 2017; 8: e107. DOI: https://doi.org/10.1038/ctg.2017.34
Vierow V, Forster C, Vogelgsang R, Dörfler A, Handwerker HO. Cerebral networks linked to itch-related sensations induced by histamine and capsaicin. Acta Derm Venereol 2015; 95: 645–652. DOI: https://doi.org/10.2340/00015555-2006
Khurana S, Singh P. Rifampin is safe for treatment of pruritus due to chronic cholestasis: a meta-analysis of prospective randomized-controlled trials. Liver Int 2006; 26: 943–948. DOI: https://doi.org/10.1111/j.1478-3231.2006.01326.x
Desbordes G, Li A, Loggia ML, Kim J, Schalock PC, Lerner E, et al. Evoked itch perception is associated with changes in functional brain connectivity. Neuroimage Clin 2015; 7: 213–221. DOI: https://doi.org/10.1016/j.nicl.2014.12.002
Arendt-Nielsen L, Morlion B, Perrot S, Dahan A, Dickenson A, Kress HG, et al. Assessment and manifestation of central sensitisation across different chronic pain conditions. Eur J Pain 2018; 22: 216–241. DOI: https://doi.org/10.1002/ejp.1140
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Copyright (c) 2025 Marcel Vetter, Theresa Buchwald, Arnd Dörfler, Clemens Forster, Andreas E. Kremer
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