High-frequency Ultrasound Reveals Epidermal-dermal Structural Alterations in an Experimental Model of Epidermolysis Bullosa

Authors

  • Karl Wallblom Division of Dermatology and Venereology, Department of Clinical Sciences Lund, Lund University, Sweden; Department of Dermatology, Skåne University Hospital, Lund, Sweden https://orcid.org/0000-0003-0947-1450
  • Artur Schmidtchen Division of Dermatology and Venereology, Department of Clinical Sciences Lund, Lund University, Sweden; Department of Dermatology, Skåne University Hospital, Lund, Sweden https://orcid.org/0000-0001-9209-3141
  • Manoj Puthia Division of Dermatology and Venereology, Department of Clinical Sciences Lund, Lund University, Sweden https://orcid.org/0000-0001-6048-7234

DOI:

https://doi.org/10.2340/actadv.v106.44438

Keywords:

Inflammation, High-frequency ultrasound, translational medical research, mechanobullous, Noninvasive diagnosis

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References

Bardhan A, Bruckner-Tuderman L, Chapple ILC, Fine JD, Harper N, Has C, et al. Epidermolysis bullosa. Nat Rev Dis Primers 2020; 6: 78. DOI: https://doi.org/10.1038/s41572-020-0210-0

Vergilio MM, Monteiro ESSA, Jales RM, Leonardi GR. High-frequency ultrasound as a scientific tool for skin imaging analysis. Exp Dermatol 2021; 30: 897–910. DOI: https://doi.org/10.1111/exd.14363

Polanska A, Danczak-Pazdrowska A, Silny W, Wozniak A, Maksin K, Jenerowicz D, et al. Comparison between high-frequency ultrasonography (Dermascan C, version 3) and histopathology in atopic dermatitis. Skin Res Technol 2013; 19: 432–437. DOI: https://doi.org/10.1111/srt.12064

Odrzywołek W, Deda A, Zdrada J, Wcisło-Dziadecka D, Lipka-Trawińska A, Błońska-Fajfrowska B, et al. Assessment of psoriatic skin features using non-invasive imaging technique. Processes 2022; 10: 985. DOI: https://doi.org/10.3390/pr10050985

Polańska A, Silny W, Jenerowicz D, Knioła K, Molińska-Glura M, Dańczak-Pazdrowska A. Monitoring of therapy in atopic dermatitis: observations with the use of high-frequency ultrasonography. Skin Res Technol 2015; 21: 35–40. DOI: https://doi.org/10.1111/srt.12153

Pazdrowski J, Danczak-Pazdrowska A, Polanska A, Kazmierska J, Barczak W, Szewczyk M, et al. An ultrasonographic monitoring of skin condition in patients receiving radiotherapy for head and neck cancers. Skin Res Technol 2019; 25: 857–861. DOI: https://doi.org/10.1111/srt.12745

Bubier JA, Sproule TJ, Alley LM, Webb CM, Fine JD, Roopenian DC, et al. A mouse model of generalized non-Herlitz junctional epidermolysis bullosa. J Invest Dermatol 2010; 130: 1819–1828. DOI: https://doi.org/10.1038/jid.2010.46

Phillips J, Reynolds KJ, Gordon SJ. Dermal thickness and echogenicity using DermaScan C high frequency ultrasound: methodology and reliability testing in people with and without primary lymphoedema. Skin Res Technol 2020; 26: 813–823. DOI: https://doi.org/10.1111/srt.12880

Wang C, Yuan J, Wu HX, Chang Y, Wang QT, Wu YJ, et al. Total glucosides of paeony inhibit the inflammatory responses of mice with allergic contact dermatitis by restoring the balanced secretion of pro-/anti-inflammatory cytokines. Int Immunopharmacol 2015; 24: 325–334. DOI: https://doi.org/10.1016/j.intimp.2014.12.026

Nystrom A, Bruckner-Tuderman L, Kiritsi D. Dystrophic epidermolysis bullosa: secondary disease mechanisms and disease modifiers. Front Genet 2021; 12: 737272. DOI: https://doi.org/10.3389/fgene.2021.737272

Almuhanna N, Wortsman X, Wohlmuth-Wieser I, Kinoshita-Ise M, Alhusayen R. Overview of ultrasound imaging applications in dermatology. J Cutan Med Surg 2021; 25: 521–529. DOI: https://doi.org/10.1177/1203475421999326

Additional Files

Published

2026-02-17

How to Cite

Wallblom, K., Schmidtchen, A., & Puthia, M. (2026). High-frequency Ultrasound Reveals Epidermal-dermal Structural Alterations in an Experimental Model of Epidermolysis Bullosa. Acta Dermato-Venereologica, 106, adv44438. https://doi.org/10.2340/actadv.v106.44438