X-linked Recessive Ectodysplasin A Mutations Induced Hypohidrotic Ectodermal Dysplasia and Severe Atopic Dermatitis Successfully Treated with Dupilumab

Authors

  • Lu Lu Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; State Key Laboratory of Complex Severe and Rare Diseases, Beijing, China; National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, China https://orcid.org/0009-0008-8925-749X
  • Jindi Feng Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; State Key Laboratory of Complex Severe and Rare Diseases, Beijing, China; National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, China https://orcid.org/0009-0001-3545-2387
  • Huimin He Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; State Key Laboratory of Complex Severe and Rare Diseases, Beijing, China; National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, China https://orcid.org/0009-0000-0895-0041
  • Yubin Peng Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; State Key Laboratory of Complex Severe and Rare Diseases, Beijing, China; National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, China https://orcid.org/0009-0003-4375-7337
  • Shiyu Zhang Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; State Key Laboratory of Complex Severe and Rare Diseases, Beijing, China; National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, China https://orcid.org/0000-0003-0923-800X
  • Lu Yang Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; State Key Laboratory of Complex Severe and Rare Diseases, Beijing, China; National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, China https://orcid.org/0000-0001-6433-9298
  • Yuehua Liu Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; State Key Laboratory of Complex Severe and Rare Diseases, Beijing, China; National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, China https://orcid.org/0000-0002-2660-0675
  • Tao Wang Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; State Key Laboratory of Complex Severe and Rare Diseases, Beijing, China; National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, China https://orcid.org/0000-0002-9998-2862

DOI:

https://doi.org/10.2340/actadv.v106.44646

Keywords:

dupilumab, hypohidrotic ectodermal dysplasia, atopic dermatitis, treatment

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References

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Published

2026-01-09

How to Cite

Lu, L., Feng, J., He, H., Peng, Y., Zhang, S., Yang, L., … Wang, T. (2026). X-linked Recessive Ectodysplasin A Mutations Induced Hypohidrotic Ectodermal Dysplasia and Severe Atopic Dermatitis Successfully Treated with Dupilumab. Acta Dermato-Venereologica, 106, adv44646. https://doi.org/10.2340/actadv.v106.44646

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