Atypical Prurigo Pigmentosa Following Ketogenic Diet: Successful Treatment with Doxycycline and Tofacitinib

Authors

  • Xiaoxiao Zhang The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou First People’s Hospital, Hangzhou City, Zhejiang Province, China
  • Zhangyu Bu The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou First People’s Hospital, Hangzhou City, Zhejiang Province, China

DOI:

https://doi.org/10.2340/actadv.v106.adv-2026-0465

Keywords:

Prurigo pigmentosa, Ketogenic diet, Tofacitinib

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References

Demircioğlu D, Durmaz EÖ, Demirkesen C, Şahin S. Prurigo pigmentosa: review of the literature, impact of ketogenic diets and proposal of a hypothesis. Indian J Dermatol 2025; 70: 146–151. DOI: https://doi.org/10.4103/ijd.ijd_464_22

Xiao A, Kopelman H, Shitabata P, Nami N. Ketogenic dietinduced prurigo pigmentosa (the “keto rash”): a case report and literature review. J Clin Aesthetic Dermatol 2021; 14: S29–S32.

Capucilli P, Wan J, Corry J, Chuang JH, Linn RL, Perman MJ. Prurigo pigmentosa: an itchy, urticarial eruption confused for food allergy. J Allergy Clin Immunol Pract 2018; 6: 1381–1382. DOI: https://doi.org/10.1016/j.jaip.2018.02.033

Liu Y, Li J, Zhou G, Wang J, Chen X, Chen S, et al. Prurigo pigmentosa: a retrospective study of 11 patients. Indian J Dermatol Venereol Leprol 2024; 90: 661–665. DOI: https://doi.org/10.25259/IJDVL_751_2023

Schwartz DM, Kanno Y, Villarino A, Ward M, Gadina M, O’Shea JJ. JAK inhibition as a therapeutic strategy for immune and inflammatory diseases. Nat Rev Drug Discov 2017; 16: 843– 862. DOI: https://doi.org/10.1038/nrd.2017.201

Navarro-Triviño FJ, Pérez-López I, Ruiz-Villaverde R. Doxycycline, an antibiotic or an anti-inflammatory agent? The most common uses in dermatology. Actas Dermosifiliogr 2020; 111: 561–566. DOI: https://doi.org/10.1016/j.adengl.2019.12.014

Rajput Khokhar A, Ghoreschi K, Huynh J. Adverse effects of Janus kinase inhibitors with relevance for daily practice in dermatology. J Dtsch Dermatol Ges 2025; 23: 1127–1140. DOI: https://doi.org/10.1111/ddg.15796

Waitayangkoon P, Moon SJ, Tirupur Ponnusamy JJ, Zeng L, Driban J, McAlindon T. Long-term safety profiles of macrolides and tetracyclines: a systematic review and meta-analysis. J Clin Pharmacol 2024; 64: 164–177. DOI: https://doi.org/10.1002/jcph.2358

Published

2026-04-14

How to Cite

Zhang, X., & Bu, Z. (2026). Atypical Prurigo Pigmentosa Following Ketogenic Diet: Successful Treatment with Doxycycline and Tofacitinib. Acta Dermato-Venereologica, 106, adv–2026. https://doi.org/10.2340/actadv.v106.adv-2026-0465

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Short Communication

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