Severe Ulceronecrotic Evolution during Mogamulizumab Treatment in a Patient with Primary Cutaneous Peripheral T-cell Lymphoma

Authors

  • Quentin Samaran Department of Dermatology, Montpellier University Hospital and Montpellier University, Montpellier, France; Epilogy (Epidemiology in Dermatology and Evaluation of therapeutics), IMRB, INSERM, Univ Paris-Est Créteil, Créteil, France; PCCEI, Univ Montpellier, INSERM, Univ Antilles, CHU Montpellier, Montpellier, France https://orcid.org/0000-0002-0560-5493
  • Marilou Duboëlle Pharmacovigilance Regional Centre, Department Of Medical Pharmacology And Toxicology, Montpellier University Hospital, Montpellier, France
  • Anaïs Marque Department of Dermatology, Montpellier University Hospital and Montpellier University, Montpellier, France
  • Virginie Bres Pharmacovigilance Regional Centre, Department Of Medical Pharmacology And Toxicology, Montpellier University Hospital, Montpellier, France https://orcid.org/0000-0001-7960-068X
  • Olivier Dereure Department of Dermatology, Montpellier University Hospital and Montpellier University, Montpellier, France; PCCEI, Univ Montpellier, INSERM, Univ Antilles, CHU Montpellier, Montpellier, France https://orcid.org/0000-0001-8736-1922

DOI:

https://doi.org/10.2340/actadv.v106.adv-2025-0279

Keywords:

Cutaneous T-Cell Lymphoma, mogamulizumab, Drug-Related side effects and adverse reactions, pharmacovigilance, primary cutaneous peripheral T-cell lymphoma

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References

Kim YH, Bagot M, Pinter-Brown L, Rook AH, Porcu P, Horwitz SM, et al. Mogamulizumab versus vorinostat in previously treated cutaneous T-cell lymphoma (MAVORIC): an international, open-label, randomised, controlled phase 3 trial. Lancet Oncol 2018; 19: 1192–1204. DOI: https://doi.org/10.1016/S1470-2045(18)30379-6

Poteligeo. European Medicines Agency (EMA). 2018. [cited 2025 November 21]. Available from: https://www.ema. europa.eu/en/medicines/human/EPAR/poteligeo

Kempf W, Mitteldorf C, Cerroni L, Willemze R, Berti E, Guenova E, et al. Classifications of cutaneous lymphomas and lymphoproliferative disorders: An update from the EORTC cutaneous lymphoma histopathology group. J Eur Acad Dermatol Venereol 2024; 38: 1491–1503. DOI: https://doi.org/10.1111/jdv.19987

G, Roccuzzo G, Pileri A, Agostinelli C, Maronese CA, Aquino C, et al. Clinicopathological definition, management and prognostic value of mogamulizumab-associated rash and other cutaneous events: a systematic review. J Eur Acad Dermatol Venereol 2024; 38: 1738–1748. DOI: https://doi.org/10.1111/jdv.19801

Hansen I, Abeck F, Menz A, Schneider SW, Booken N. Mogamulizumab-associated rash - case series and review of the literature. J Dtsch Dermatol Ges 2024; 22: 1079–1086. DOI: https://doi.org/10.1111/ddg.15432

Barré M, Valois A, Okhremchuk I, Sair M, Masbou J, Abed S, et al. Ecthyma gangrenosum complicating mogamulizumab treatment of Sézary syndrome. Ann Dermatol Venereol 2021; 148: 63–65. DOI: https://doi.org/10.1016/j.annder.2020.09.576

Bégaud B, Evreux JC, Jouglard J, Lagier G. Imputation of the unexpected or toxic effects of drugs. Actualization of the method used in France. Therapie 1985; 40: 111–118.

Suzuki Y, Saito M, Ishii T, Urakawa I, Matsumoto A, Masaki A, et al. Mogamulizumab treatment elicits autoantibodies attacking the skin in patients with adult T-cell leukemialymphoma. Clin Cancer Res 2019; 25: 4388–4399. DOI: https://doi.org/10.1158/1078-0432.CCR-18-2575

Published

2026-04-20

How to Cite

Samaran, Q., Duboëlle, M., Marque, A., Bres, V., & Dereure, O. (2026). Severe Ulceronecrotic Evolution during Mogamulizumab Treatment in a Patient with Primary Cutaneous Peripheral T-cell Lymphoma. Acta Dermato-Venereologica, 106, adv–2025. https://doi.org/10.2340/actadv.v106.adv-2025-0279