A Rare Soft Tissue Presentation of Mixed Histiocytosis with Multiple Disseminated Subcutaneous Masses

Authors

  • Fumi Miyagawa Department of Dermatology, Nara Medical University School of Medicine, Kashihara, Nara 634-8522, Japan https://orcid.org/0000-0002-2030-6969
  • Kohei Ogawa Department of Dermatology, Nara Medical University School of Medicine, Kashihara, Nara 634-8522, Japan
  • Maiko Takeda Department of Diagnostic Pathology, Nara Medical University School of Medicine, 840 Shijo, Kashihara, Nara 634-8522, Japan
  • Akihiko Yoshizawa Department of Diagnostic Pathology, Nara Medical University School of Medicine, 840 Shijo, Kashihara, Nara 634-8522, Japan
  • Hideo Asada Department of Dermatology, Nara Medical University School of Medicine, Kashihara, Nara 634-8522, Japan

DOI:

https://doi.org/10.2340/actadv.v106.adv-2025-0031

Keywords:

Langerhans cell histiocytosis, macrophages, lymphoma

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References

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Berres ML, Lim KPH, Peters T, Price J, Takizawa H, Salmon H, et al. BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups. J Exp Med 2014; 211: 669–683. DOI: https://doi.org/10.1084/jem.20130977

Haroche J, Cohen-Aubart F, Rollins BJ, Donadieu J, Charlotte F, Idbaih A, et al. Histiocytoses: emerging neoplasia behind inflammation. Lancet Oncol 2017; 18: e113–e125. DOI: https://doi.org/10.1016/S1470-2045(17)30031-1

Emile JF, Abla O, Fraitag S, Horne A, Haroche J, Donadieu J, et al. Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages. Blood 2016; 127: 2672–2681. DOI: https://doi.org/10.1182/blood-2016-01-690636

Picarsic J, Bychkov A, Calaminici M, Demicco EG, Jacques TS, Narula G. Langerhans cell histiocytosis. In: WHO classification of Tumours Editorial Board. Haematolymphoid Tumours Part A. Lyon: IARC; 2024: p. 230–233.

Emile JF, Berti E, Demicco EG, Haroche J, Sahm F, Tirabosco R, et al. Erdheim-Chester disease. In: WHO classification of Tumours Editorial Board. Haematolymphoid Tumours Part A. Lyon: IARC; 2024: p. 245–247.

Edelbroek JR, Vermeer MH, Jansen PM, Stoof TJ, van der Linden MMD, Horváth B, et al. Langerhans cell histiocytosis first presenting in the skin in adults: frequent association with a second haematological malignancy. Br J Dermatol 2012; 167: 1287–1294. DOI: https://doi.org/10.1111/j.1365-2133.2012.11169.x

Luder CM, Nordmann TM, Ramelyte E, Mühleisen B, Kerl K, Guenova E, et al. Histiocytosis - cutaneous manifestations of hematopoietic neoplasm and non-neoplastic histiocytic proliferations. J Eur Acad Dermatol Venereol 2018; 32: 926–934. DOI: https://doi.org/10.1111/jdv.14794

Chasset F, Barete S, Charlotte F, Cohen-Aubart F, Arnaud L, Le Pelletier F, et al. Cutaneous manifestations of Erdheim-Chester disease (ECD): clinical, pathological, and molecular features in a monocentric series of 40 patients. J Am Acad Dermatol 2016; 74: 513–520. DOI: https://doi.org/10.1016/j.jaad.2015.11.007

Ozkaya N, Rosenblum MK, Durham BH, Pichardo JD, Abdel-Wahab O, Hameed MR, et al. The histopathology of Erdheim-Chester disease: a comprehensive review of a molecularly characterized cohort. Mod Pathol 2018; 31: 581–597. DOI: https://doi.org/10.1038/modpathol.2017.160

Pivkova-Veljanovska A, Ivanovski M, Panovska-Stavridis I, Stojanoski Z, Trajkova S, Karadzova-Stojanoska A, et al. A rare case of soft tissue Erdheim-Chester disease: diagnostic dilemma and management. Open Access Maced J Med Sci 2019; 7: 1808–1811. DOI: https://doi.org/10.3889/oamjms.2019.231

Kobic A, Shah KK, Schmitt AR, Goyal G, Go RS, Guo R, et al. Erdheim-Chester disease: expanding the spectrum of cutaneous manifestations. Br J Dermatol 2020; 182: 405–409. DOI: https://doi.org/10.1111/bjd.18153

Suster DI, Ronen S, Suster S. Selected case from the Arkadi M. Rywlin International Pathology Slide Seminar: involvement of skin and soft tissue by Erdheim-Chester disease. Adv Anat Pathol 2024; 31: 271–274. DOI: https://doi.org/10.1097/PAP.0000000000000429

Published

2026-05-21

How to Cite

Miyagawa, F., Ogawa, K., Takeda, M., Yoshizawa, A., & Asada, H. (2026). A Rare Soft Tissue Presentation of Mixed Histiocytosis with Multiple Disseminated Subcutaneous Masses. Acta Dermato-Venereologica, 106, adv–2025. https://doi.org/10.2340/actadv.v106.adv-2025-0031

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Short Communication

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