Immunopathological investigations in purpura pigmentosa chronica
DOI:
https://doi.org/10.2340/000155556910110Abstract
We studied the cell infiltrates and antigenic characteristics of keratinocytes in biopsies from purpura pigmentosa chronica (PPC), with eleven monoclonal antibodies against several cell surface markers of effector and/or accessory cells of the immune system and compared the reactivity patterns with those in biopsies from uninvolved skin. Immunohistochemical staining revealed a predominance of activated helper T lymphocytes in the cutaneous inflammatory infiltrate. In contrast to uninvolved skin, lesional keratinocytes were found to express HLA-DR, OKM5, Leu-8 and Leu-11b (CD16) antigens in all biopsies from the involved skin. We demonstrate here for the first time the in vivo expression of several effector and/or accessory cell markers on lesional keratinocytes and infiltrate cells in PPC.Downloads
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Copyright (c) 1989 M Simon Jr, A Heese, A Götz
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