Real-world Clinical Efficacy and Patient-reported Treatment Satisfaction of Nemolizumab Treatment in Prurigo Nodularis

Authors

  • Yoshihito Mima Department of Dermatology, Tokyo Metropolitan Police Hospital, Tokyo, Japan https://orcid.org/0009-0000-4832-1899
  • Masako Yamamoto Department of Dermatology, Tokyo Metropolitan Police Hospital, Tokyo, Japan
  • Ken Iozumi Department of Dermatology, Tokyo Metropolitan Police Hospital, Tokyo, Japan

DOI:

https://doi.org/10.2340/actadv.v106.adv-2026-0380

Keywords:

Nemolizumab, atopic dermatitis, Prurigo nodularis, Patient-reported outcome, Daily topical treatment time, daily preoccupation time

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References

Pereira MP, Hoffmann V, Weisshaar E, Wallengren J, Halvorsen JA, Garcovich S, et al. Chronic nodular prurigo: clinical profile and burden. A European cross-sectional study. J Eur Acad Dermatol Venereol 2020; 34: 2373–2383. DOI: https://doi.org/10.1111/jdv.16309

Kwatra SG, Pereira MP, Misery L, Mollanazar NK, Shah P, Wiggins S. Prurigo nodularis: disease burden, clinical features and approach to management. Br J Dermatol 2025; 193: 642–652. DOI: https://doi.org/10.1093/bjd/ljaf213

Igarashi A, Yoshida T, Sunaga Y, Nawata H, Arima K. Current status of prurigo nodularis in Japan: a retrospective study using a health insurance claims database. J Clin Med 2025; 14: 1872. DOI: https://doi.org/10.3390/jcm14061872

Waitek M, Weisshaar E. The epidemiology of chronic prurigo: lessons learned. Acta Derm Venereol 2025; 105: adv44334. DOI: https://doi.org/10.2340/actadv.v105.44334

Murota H, Matsumoto M, Arima K, Yoshida T, Fujita H. Current clinical practice of prurigo nodularis in Japan: a cross-sectional web-survey among dermatologists. J Dermatol 2025; 52: 348–352. DOI: https://doi.org/10.1111/1346-8138.17400

Murota H, Arima K, Yoshida T, Fujita H. Disease burden and treatment satisfaction in patients with prurigo nodularis in Japan. J Dermatol 2024; 51: 223–233. DOI: https://doi.org/10.1111/1346-8138.17045

Yosipovitch G, Mollanazar N, Ständer S, Kwatra SG, Kim BS, Laws E, et al. Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials. Nat Med 2023; 29: 1180–1190. DOI: https://doi.org/10.1038/s41591-023-02320-9

Ständer S, Yosipovitch G, Lacour JP, Legat FJ, Paul C, Reich A, et al. Nemolizumab efficacy in prurigo nodularis: onset of action on itch and sleep disturbances. J Eur Acad Dermatol Venereol 2022; 36: 1820–1825. DOI: https://doi.org/10.1111/jdv.18377

Kwatra SG, Ständer S, Yosipovitch G, Kim BS, Levit NA, O’Malley JT. Pathophysiology of prurigo nodularis: neuroimmune dysregulation and the role of type 2 inflammation. J Invest Dermatol 2025; 145: 249–256. DOI: https://doi.org/10.1016/j.jid.2024.06.1276

Kwatra SG, Yosipovitch G, Legat FJ, Reich A, Paul C, Simon D, et al. Phase 3 trial of nemolizumab in patients with prurigo nodularis. N Engl J Med 2023; 389: 1579–1589. DOI: https://doi.org/10.1056/NEJMoa2301333

Legat FJ, Kwatra SG, Reich A, Boulinguez S, Tsianakas A, Sauder M, et al. Nemolizumab in prurigo nodularis up to 100 weeks: OLYMPIA LTE interim analysis. J Eur Acad Dermatol Venereol 2025.

Phan NQ, Blome C, Fritz F, Gerss J, Reich A, Ebata T, et al. Assessment of pruritus intensity: prospective study on validity and reliability of the visual analogue scale, numerical rating scale and verbal rating scale in 471 patients with chronic pruritus. Acta Derm Venereol 2012; 92: 502–507. DOI: https://doi.org/10.2340/00015555-1246

Zeidler C, Pereira MP, Augustin M, Spellman M, Ständer S. Investigator’s global assessment of chronic prurigo: a new instrument for use in clinical trials. Acta Derm Venereol 2021; 101: adv00401. DOI: https://doi.org/10.2340/00015555-3701

Mima Y, Yamamoto M, Iozumi K. Cutaneous adverse events following nemolizumab administration: a review. J Clin Med 2025; 14: 3026. DOI: https://doi.org/10.3390/jcm14093026

Mima Y, Yamamoto M, Iozumi K. The absence of recent systemic therapy can be a significant risk factor for nemolizumab-associated cutaneous adverse events in patients with prurigo nodularis: a single-centre retrospective study. Acta Derm Venereol 2025; 105: adv44310. DOI: https://doi.org/10.2340/actadv.v105.44310

Additional Files

Published

2026-06-22

How to Cite

Mima, Y., Yamamoto, M., & Iozumi, K. (2026). Real-world Clinical Efficacy and Patient-reported Treatment Satisfaction of Nemolizumab Treatment in Prurigo Nodularis. Acta Dermato-Venereologica, 106, adv–2026. https://doi.org/10.2340/actadv.v106.adv-2026-0380

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