Effectiveness of Baricitinib in Treating Atopic Dermatitis in Difficult-to-treat Areas: A Retrospective Real-world Study

Authors

  • Giuseppe Lauletta Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy https://orcid.org/0009-0007-5607-8877
  • Maddalena Napolitano Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy https://orcid.org/0000-0003-3309-8190
  • Claudio Brescia Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy https://orcid.org/0009-0007-5094-5052
  • Francesca di Vico Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy
  • Melania Parisi Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy
  • Cataldo Patruno Department of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, Campobasso, Italy https://orcid.org/0000-0001-8661-2822

DOI:

https://doi.org/10.2340/actadv.v106.adv-2026-0386

Keywords:

Atopic dermatitis, Baricitinib, Difficult-to-treat areas, Real-world study, Quality of life

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References

Langan SM, Irvine AD, Weidinger S. Atopic dermatitis. Lancet 2020; 396: 345–360. DOI: https://doi.org/10.1016/S0140-6736(20)31286-1

Napolitano M, Potestio L, Pezzolo E, Rossi M, Saboya R, Galli B, et al. Efficacy of abrocitinib and baricitinib on “difficult-to-treat areas” in patients with atopic dermatitis: a multicentre study. Clin Exp Dermatol 2025; 50: 863–865. DOI: https://doi.org/10.1093/ced/llae415

Simpson EL, Lacour JP, Spelman L, Galimberti R, Eichenfield LF, Bissonnette R, et al. Baricitinib in patients with moderate-to-severe atopic dermatitis and inadequate response to topical corticosteroids: results from two randomized monotherapy phase III trials. Br J Dermatol 2020; 183: 242–255. DOI: https://doi.org/10.1111/bjd.18898

Gori N, Di Nardo L, Ippoliti E, Antonelli F, Boeti L, Balato A, et al. Baricitinib for adult atopic dermatitis: real-world effectiveness, safety, and response predictors. J Dermatolog Treat 2025; 36: 2578249. DOI: https://doi.org/10.1080/09546634.2025.2578249

Reich K, DeLozier AM, Nunes FP, Thyssen JP, Eichenfield LF, Wollenberg A, et al. Baricitinib improves symptoms in patients with moderate-to-severe atopic dermatitis and inadequate response to topical corticosteroids: patient-reported outcomes from two randomized monotherapy phase III trials. J Dermatolog Treat 2022; 33: 1521–1530. DOI: https://doi.org/10.1080/09546634.2020.1839008

Reguiai Z, Becherel PA, Perrot JL, Fougerousse AC, Begon E, Poreaux C, et al. Impact of baricitinib on patients’ quality of life after one year of treatment for atopic dermatitis in real-world practice: results of the observatory of chronic inflammatory skin diseases registry. Acta Derm Venereol 2023; 103: adv14153. DOI: https://doi.org/10.2340/actadv.v103.14153

Lauletta G, Patruno C, Brescia C, Cosenza A, D’Elia C, Ventura V, et al. Head and neck dermatitis in atopic dermatitis: a narrative review of pathogenesis, clinical challenges, and therapeutic strategies. Antibodies 2025; 14: 104. DOI: https://doi.org/10.3390/antib14040104

Holness DL, Beaton D, Harniman E, DeKoven J, Skotnicki S, Nixon R, et al. Hand and upper extremity function in workers with hand dermatitis. Dermatitis 2013; 24: 131–136. DOI: https://doi.org/10.1097/DER.0b013e3182910416

Woo YR, Han Y, Lee JH, Lee YB, Kim JE, Kim M, et al. Real-world prevalence and burden of genital eczema in atopic dermatitis: a multicenter questionnaire-based study. J Dermatol 2021; 48: 625–632. DOI: https://doi.org/10.1111/1346-8138.15817

Misery L, Seneschal J, Reguiai Z, Merhand S, Héas S, Huet F, et al. The impact of atopic dermatitis on sexual health. J Eur Acad Dermatol Venereol 2019; 33: 428–432. DOI: https://doi.org/10.1111/jdv.15223

Napolitano M, Fabbrocini G, Kastl S, Battista T, Di Guida A, Martora F, et al. Effect of dupilumab on sexual desire in adult patients with moderate to severe atopic dermatitis. Medicina 2022; 58: 1708. DOI: https://doi.org/10.3390/medicina58121708

Published

2026-07-14

How to Cite

Lauletta, G., Napolitano, M., Brescia, C., di Vico, F., Parisi, M., & Patruno, C. (2026). Effectiveness of Baricitinib in Treating Atopic Dermatitis in Difficult-to-treat Areas: A Retrospective Real-world Study. Acta Dermato-Venereologica, 106, adv–2026. https://doi.org/10.2340/actadv.v106.adv-2026-0386

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