Successful Treatment of Paediatric Morphea with Tofacitinib
DOI:
https://doi.org/10.2340/actadv.v103.4805Keywords:
Scleroderma, Localized, tofacitinib, Biopsy, MyofibroblastsAbstract
Abstract is missing (Short communication)
Downloads
References
Albuquerque JVD, Andriolo BN, Vasconcellos MR, Civile VT, Lyddiatt A, Trevisani VF. Interventions for morphea. Cochrane Database Syst Rev 2019; 7: CD005027.
https://doi.org/10.1002/14651858.CD005027.pub5 DOI: https://doi.org/10.1002/14651858.CD005027.pub5
You H, Xu D, Zhao J, Li J, Wang Q, Tian X, et al. JAK inhibitors: prospects in connective tissue diseases. Clin Rev Allergy Immunol 2020; 59: 334-351.
https://doi.org/10.1007/s12016-020-08786-6 DOI: https://doi.org/10.1007/s12016-020-08786-6
Damsky W, Patel D, Garelli CJ, Garg M, Wang A, Dresser K, et al. JAK inhibition prevents bleomycin-induced fibrosis in mice and is effective in patients with morphea. J Invest Dermatol 2020; 140: 1446-1449.
https://doi.org/10.1016/j.jid.2019.12.019 DOI: https://doi.org/10.1016/j.jid.2019.12.019
Richard SA. Exploring the pivotal immunomodulatory and anti-inflammatory potentials of glycyrrhizic and glycyrrhetinic acids. Mediators Inflamm 2021; 2021: 6699560.
https://doi.org/10.1155/2021/6699560 DOI: https://doi.org/10.1155/2021/6699560
Kelsey CE, Torok KS. The localized scleroderma cutaneous assessment tool: responsiveness to change in a pediatric clinical population. J Am Acad Dermatol 2013; 69: 214-220.
https://doi.org/10.1016/j.jaad.2013.02.007 DOI: https://doi.org/10.1016/j.jaad.2013.02.007
Groot N, de Graeff N, Avcin T, Bader-Meunier B, Brogan P, Dolezalova P, et al. European evidence-based recommendations for diagnosis and treatment of childhood-onset systemic lupus erythematosus: the SHARE initiative. Ann Rheum Dis 2017; 76: 1788-1796.
https://doi.org/10.1136/annrheumdis-2016-210960 DOI: https://doi.org/10.1136/annrheumdis-2016-210960
Stevens WG, Gould DJ, Pham LD, Jimenez Lozano JN. Molecular and histological evidence detailing clinically observed skin improvement following cryolipolysis. Aesthet Surg J 2022; 42: 56-67.
https://doi.org/10.1093/asj/sjab226 DOI: https://doi.org/10.1093/asj/sjab226
Wang P, Guo W, Liu S. A rare case of juvenile localised scleroderma with intra-oral and dental involvement. Exp Ther Med 2015; 10: 2213-2215.
https://doi.org/10.3892/etm.2015.2791 DOI: https://doi.org/10.3892/etm.2015.2791
Kumar AB, Blixt EK, Drage LA, El-Azhary RA, Wetter DA. Treatment of morphea with hydroxychloroquine: a retrospective review of 84 patients at Mayo clinic, 1996-2013. J Am Acad Dermatol 2019; 80: 1658-1663.
https://doi.org/10.1016/j.jaad.2019.01.040 DOI: https://doi.org/10.1016/j.jaad.2019.01.040
Walker D, Susa JS, Currimbhoy S, Jacobe H. Histopathological changes in morphea and their clinical correlates: results from the morphea in adults and children cohort V. J Am Acad Dermatol 2017; 76: 1124-1130.
https://doi.org/10.1016/j.jaad.2016.12.020 DOI: https://doi.org/10.1016/j.jaad.2016.12.020
Torok KS, Kurzinski K, Kelsey C, Yabes J, Magee K, Vallejo AN, et al. Peripheral blood cytokine and chemokine profiles in juvenile localized scleroderma: T-helper cell-associated cytokine profiles. Semin Arthritis Rheu 2015; 45: 284-293.
https://doi.org/10.1016/j.semarthrit.2015.06.006 DOI: https://doi.org/10.1016/j.semarthrit.2015.06.006
Chakraborty D, Šumová B, Mallano T, Chen C, Distler A, Bergmann C, et al. Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis. Nat Commun 2017; 8: 1130.
https://doi.org/10.1038/s41467-017-01236-6 DOI: https://doi.org/10.1038/s41467-017-01236-6
Celada LJ, Kropski JA, Herazo-Maya JD, Luo W, Creecy A, Abad AT, et al. PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production. Sci Transl Med 2018; 10: eaar8356.
https://doi.org/10.1126/scitranslmed.aar8356 DOI: https://doi.org/10.1126/scitranslmed.aar8356
Seif F, Khoshmirsafa M, Aazami H, Mohsenzadegan M, Sedighi G, Bahar M. The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells. Cell Commun Signal 2017; 15: 23.
https://doi.org/10.1186/s12964-017-0177-y DOI: https://doi.org/10.1186/s12964-017-0177-y
McGaugh S, Kallis P, De Benedetto A, Thomas RM. Janus kinase inhibitors for treatment of morphea and systemic sclerosis: a literature review. Dermatol Ther 2022; 35: e15437.
https://doi.org/10.1111/dth.15437 DOI: https://doi.org/10.1111/dth.15437
Published
How to Cite
Issue
Section
Categories
License
Copyright (c) 2023 Jun-Chi Tang, Wen-Yue Zheng; Guang-Ming Han, Shuang-fei Liu; Bin Yang
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.
Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.