Topical application of clobetasol-17-propionate inhibits the intra-epidermal accumulation of polymorphonuclear leukocytes

Authors

  • A Chang
  • PC. van de Kerkhof

DOI:

https://doi.org/10.2340/00015555685760

Abstract

The in vivo effect of topical clobetasol-17-propionate (CP) on the leukotriene B4- and trauma-induced intra-epidermal accumulation of polymorphonuclear leukocytes (PMN) was investigated in normal volunteers. PMN accumulation was assessed using elastase, a specific and sensitive marker for these cells. A profound inhibition of PMN accumulation was shown in the first 2 days of treatment with CP, an effect that faded away after a treatment of 2 weeks.

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Published

1988-01-01

How to Cite

Chang, A., & van de Kerkhof, P. (1988). Topical application of clobetasol-17-propionate inhibits the intra-epidermal accumulation of polymorphonuclear leukocytes. Acta Dermato-Venereologica, 68(1), 57–60. https://doi.org/10.2340/00015555685760

Issue

Section

Articles