Serum Infliximab Concentrations in Psoriatic Patients Treated with Infliximab: A Systematic Review

Authors

  • Carole Dannepond
  • Annabel Maruani
  • Laurent Machet
  • David Ternant
  • Gilles Paintaud
  • Mahtab Samimi

DOI:

https://doi.org/10.2340/00015555-1980

Keywords:

infliximab, psoriasis, pharmacokinetics, trough concentration

Abstract

The efficacy of infliximab is influenced by individual variability in its pharmacokinetics and pharmacodynamics. Serum infliximab concentrations could therefore be related to the efficacy and tolerance of infliximab, and assist adjustment of treatment. The aim of this systematic review was to assess the value of measuring serum infliximab concentrations in psoriatic patients. A bibliographic search was performed on MEDLINE, CENTRAL, EMBASE, LILACS for original studies on serum infliximab concentrations in psoriatic patients treated with infliximab. Ten articles were included, representing evaluation of serum infliximab concentrations in 733 patients. Predictive value of higher serum infliximab concentrations on long-term response maintenance was suggested in 3 studies. There was no information regarding the value of such measurements for adjustment of infliximab dosage. Trough serum infliximab concentrations that are at least detectable (>0.1 mg/L) at steady state (week 22) seem to be associated with maintaining a clinical response in the long term.

Downloads

Download data is not yet available.

Downloads

Additional Files

Published

2014-11-03

How to Cite

Dannepond, C., Maruani, A., Machet, L., Ternant, D., Paintaud, G., & Samimi, M. (2014). Serum Infliximab Concentrations in Psoriatic Patients Treated with Infliximab: A Systematic Review. Acta Dermato-Venereologica, 95(4), 401–406. https://doi.org/10.2340/00015555-1980

Issue

Vol. 95 No. 4 (2015)

Section

Articles

License

Copyright (c) 2014 Carole Dannepond, Annabel Maruani, Laurent Machet, David Ternant, Gilles Paintaud, Mahtab Samimi

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.

Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.

Crossref
Scopus
Google Scholar
Europe PMC